探讨Visfatin与糖脂代谢及2型糖尿病患者轻度认知障碍的相关性

Relationship between blood levels of visfatin and glycolipid metabolism and mild cognitive impair- ment in patients with type 2 diabetes

目的探讨老年2型糖尿病患者（T2DM）发生轻度认知功能障碍（MCI）与内脏脂肪素（visfatin）和糖脂代谢的相关性。方法选取2016年2月至2017年1月本院收治的91例T2DM患者，采集空腹血检测相关实验室指标，使用蒙特利尔认知评估量表（MoCA）测定认知功能。结果91例T2DM患者中有50例发生MCI。与非MCI组相比，MCI组年龄、总胆固醇、胰岛素、胰岛素抵抗指数、visfatin、MoCA评分和糖尿病性视网膜病变等指标比较差异有统计学意义（P〈0．05）。MoCA评分与visfatin、胰岛素抵抗指数均呈负相关（r=-0．38，-0．22，P〈0．05）。糖尿病性视网膜病变、胰岛素抵抗指数、年龄和visfatin是T2DM患者发生MCI的独立危险因素。结论年龄越大、伴有糖尿病性视网膜病变、胰岛素抵抗指数越大和visfatin水平越高的T2DM患者发生MCI风险越大。

Objective To explore the relationship between blood levels of visfatin and glycolipid metabolism and mild cognitive impairment （MCI） in patients with type 2 diabetes （T2DM）. Methods From February 2016 to January 2017, a total of 91 patients with T2DM were recruited as investigation objects. Cognitive function was measured by Montreal Cognitive Assessment （MoCA） , and fasting serum was collected to determine the relevant laboratory indexes. Results In the 91 patients, 50 cases developed MCI. Compared to non-MCI group, MCI group had significant difference in age, total cholesterol, insulin, insulin resistance index, visfatin, MoCA score and diabetic retinopathy （P 〈 0. 05）. Pearson conelation analysis showed that the MoCA score was negatively correlated with visfatin and insulin resistance index （ P 〈 0. 05）. Further logistic regression analysis showed that age, diabetic retinopathy, insulin resistance index and visfatin were independent risk factors for MCI in T2DM patients. Conclusions MCI in T2DM patients increases with the increasing of eider, diabetic retinopathy, insulin resistance index, and visfatin.