摘要
目的探讨伴下肢动脉粥样硬化斑块(lower extremity atherosclerosis, LEA)的急性缺血性卒中患者的危险因素。方法回顾性连续纳入发病7 d内住院的急性缺血性卒中患者。采用彩色多普勒探测仪检测LEA,确定并分析人口统计学特征、血管危险因素和实验室指标。结果共纳入156例急性缺血性卒中患者,138例伴有LEA。单变量分析显示,LEA组年龄[(69.5±11.8)岁对(60.4±11.5)岁;t=3.063,P=0.003]和高血压患者的比例(81.1%对55.6%;χ2=2.467,P=0.014)显著高于非LEA组。多变量logistic回归分析显示,在校正性别、基线收缩压、糖尿病、缺血性心脏病等混杂因素后,年龄[优势比(odds ratio, OR) 1.059,95%可信区间(confidence interval, CI)1.016~1.105;P=0.007]和高血压(OR 3.128,95% CI 1.084~9.026,P=0.035)为伴LEA的急性缺血性卒中的独立危险因素。结论年龄和高血压与伴LEA的急性缺血性卒中有关。
ObjectiveTo investigate the risk factors for acute ischemic stroke in patients with lower extremity atherosclerosis (LEA).MethodsThe consecutive patients with acute ischemic stroke admitted to hospital within 7 d after onset were enrolled retrospectively. Color Doppler flow imaging was used to detect LEA. The demographic characteristics, vascular risk factors, and laboratory parameters were identified and analyzed.ResultsA total of 156 patients with acute ischemic stroke were enrolled, including 138 with LEA. Univariate analysis showed that age (69.5±11.8 years vs. 60.4±11.5 years; t=3.063, P=0.003) and the proportion of patients with hypertension (81.1% vs. 55.6%; χ2=2.467, P=0.014) in the LEA group were significantly higher than those in the non-LEA group. Multivariate logistic regression analysis showed that after adjustment for confounders such as gender, baseline systolic blood pressure, diabetes mellitus, and ischemic heart disease, age (odds ratio [OR] 1.059, 95% confidence interval [CI] 1.016-1.105; P=0.007), and hypertension (OR 3.128, 95% CI 1.084-9.026, P=0.035) were the independent risk factors for acute ischemic stroke complicated with LEA.ConclusionsAge and hypertension are associated with acute ischemic stroke complicated with LEA.
出处
《国际脑血管病杂志》
2017年第9期805-808,共4页
International Journal of Cerebrovascular Diseases
基金
苏州市科技发展计划课题(SYSD2015046)
关键词
卒中
脑缺血
外周血管疾病
动脉粥样硬化
下肢
超声检查
多普勒
彩色
危险因素
Stroke
Brain Ischemia
Peripheral Vascuhr Diseases
Atherosclerosis
Lower Extremity
Ultrasonography, Doppler, Color
Risk Factors