衰老细胞组织内累积与衰老相关疾病

Accumulation of Senescent Cells in Tissues and Aging Related Diseases

细胞衰老是指在应激状态下细胞不可逆地持续性增殖抑制。与细胞凋亡不同,衰老细胞可以抵抗凋亡并长期存活,当衰老的细胞不能被免疫细胞有效清除时,随时间延长在组织内累积,并分泌过多的各种细胞因子使组织微环境发生改变,影响周围正常细胞分化生长导致组织和器官恶化,对机体衰老和衰老相关疾病有促进作用。因此,清除衰老细胞成为治疗衰老相关疾病的新策略。该文主要介绍体细胞衰老的分类,细胞衰老在2型糖尿病、肺纤维化和骨关节炎发病过程中的作用。

Cell senescence refers to the irreversible continuous proliferation inhibition of cells under stress. Different from apoptosis, senescent cell can resist apoptosis and survive for a long time. When the aging ceils cannot be effectively removed by the immune cells,and accumulate within the tissue gradually,which secrete various cytokines causing microen- vironment changes, can affect the surrounding normal cell differentiation and growth,resulting in the deterioration of tissues and organs, therefore act as a contributor to aging and aging related diseases. Therefore, clearing senescent cells has become a new strategy for the treatment of aging related diseases. Here is to introduce the type of cell senescence, senescent cell accruing in process of type 2 diabetes mellitus, idiopathic pulmonary fibrosis and osteoarthritis.