摘要
树突状细胞(DCs)是最强大的抗原呈递细胞,根据成熟状态分为未成熟DCs和成熟DCs。未成熟DCs识别、捕获抗原,成为成熟DCs;成熟DCs呈递抗原到T淋巴细胞,并活化初始T淋巴细胞,与T细胞共同参与免疫反应。细胞因子信号转导抑制蛋白1(SOCS1)是酪氨酸激酶信号转导及转录激活信号通路的负向调控因子。SOCS1受DCs、T细胞及其他细胞分泌的细胞因子调控,参与DCs、T细胞的分化、活化,且通过调控DCs、T细胞参与肿瘤、皮肤病等多种疾病的发生。因此,研究疾病中SOCS1调控DCs、T细胞的机制可为肿瘤、自身免疫性疾病等多种疾病提供新的治疗思路。
Dendritic cells （DCs） are the most potent antigen-presenting cells, which are divided into immature DCs and mature DCs according to their mature state. Immature DCs recognize and capture antigen to become mature DCs;the mature DCs present antigens to T lymphocytes,and activate the initial T lymphocytes, and participate in the immune response with T cells. Suppressor of cytokine signaling 1 （ SOCS1 ） is a negative regulator of tyrosine kinase signal transduction and tran- scriptional activation signaling pathways. SOCS1 is regulated by DCs, cytokines from DCs, T cells and other cells, involved in DCs, T cell differentiation, activation, and involved in tumors, skin diseases and other diseases by regulating DCs, T ceils. Therefore, the study of disease in SOCS1 regulation of DCs, T cell mechanism may provide new treatment ideas for the treatment of tumor, autoimmune diseases and other diseases.
出处
《医学综述》
2017年第23期4616-4621,共6页
Medical Recapitulate
基金
国家自然科学基金(81460008)
