降钙素原与肺部感染多重耐药鲍曼不动杆菌患者病情程度的相关性

The relationship between calcitonin and severity of multiple infection in patients with pulmonary infection

目的评价血清降钙素原(PCT)与肺部感染多重耐药鲍曼不动杆菌(MDRAB)患者病情严重程度的相关性。方法肺部感染MDRAB病人116例,于入院第1、3、7天检测血清PCT,按肺炎严重度指数(PSI)分为低危组、中危组和高危组,比较不同组的PCT水平及其随时间的变化,并对PCT与PSI的相关性进行Spearman相关分析。结果低危组(41例)占35.34%,中危组(56例)占48.28%,高危组(19例)占16.38%。入院时高危组的PCT阳性率为89.47%,显著高于中危组(75%)与低危组(26.83%,P<0.05);随治疗时间的延长,各组血清PCT水平均呈明显下降趋势(P<0.05);Spearman相关分析显示,PCT与PSI分值呈较强的正相关(r=0.727,P<0.05)。结论血清PCT与肺部感染MDRAB患者的病情严重程度呈正相关,监测其PCT水平能指导治疗及评估预后。

Objective To evaluate the correlation between serum procalcitonin（ PCT） and severity of pulmonary infection in patients with multi-drug resistant Acinetobacter baumannii（ MDRAB）.Methods 116 patients with MDRAB were enrolled. Serum PCT was detected on the 1 st,3 rd and 7 th day of admission. According to the severity index of pneumonia（ PSI）,the patients were divided into low risk and high risk groups. The PCT level and their changes with time were compared between different groups,and the correlation between PCT and PSI was analyzed by Spearman correlation. Results The positive rate of PCT in high risk group was 89. 47%,which was significantly higher than that in middle risk group（ 75.00%） and low risk group（ 26.83%）（ P〈0. 05）. Spearman correlation analysis showed that there was a positive correlation between PCT and PSI scores（ r = 0.727,P〈0. 05）. Conclusions Serum PCT is positively correlated with the severity of MDRAB in patients with pulmonary infection,and monitoring PCT level could guide the treatment and evaluate the prognosis.