上海社区中老年人群胆石症与非酒精性脂肪性肝病的相关性研究

Association between gallstone and non-alcoholic fatty liver disease in middle-aged and elderly Chinese in Shanghai local communities

目的探讨上海社区中老年人群胆石症与非酒精性脂肪性肝病（NOn—alcoholic fatty liver disease，NAFLD）的相关性。方法采取整群抽样的方法，对上海市嘉定区8934名40岁及以上居民进行问卷调查和体格检查．采集胆石症相关病史，并检测血糖、血脂及肝酶等生化指标。所有受试者行高分辨腹部超声检查。结果既往无胆石症病史的受试者与既往有胆石症病史的患者，其NAFLD的患病率分别为28．8％和42．9％（P〈0．01）。多元logistic回归分析表明，以无胆石症病史患者为参照，既往胆石症病史阳性者NAFLD的患病风险显著增加，比值比（OR）[95％可信区间（a）]为1．39（1．45—1．69）；以既往未行胆囊切除术的受试者为参照，行胆囊切除术的受试者NAFLD的患病风险亦显著增加[OR（95％CI）为1．44（1．04-1．99）]。结论上海社区中老年人群胆石症阳性与NAFLD患病风险增加显著相关。

Objective To investigate the association between gallstone and non-alcoholic fatty liver disease （NAFLD） in middle-aged and elderly Chinese. Methods A cross-sectional study was conducted in 8934 Chinese adults from Jiading District, Shanghai. Questionnaire interview, anthropometric measurements, biochemical evaluation, and abdominal ultrasonography were performed in all the participants. Results Compared with participants without gallstone, individuals with gallstone had significantly higher prevalence of NAFLD （28.8% and 42.9%, respectively; P〈O. 01 ）. Using participants without gallstone as the reference, participants with gallstone were associated with an increased risk of NAFLD after adjustment for multiple covariates [ odds ratios（OR） and 95% confidence interval（CI） was 1.39 （1.45-1.69） ]. In addition, compared with participants without cholecystectomy, participants with cholecystectomy were associated with an increased risk of NAFLD （ OR = 1.44, 95% CI 1.04- 1.99）. Conclusion The presence of gallstone and eholecystectomy were positively associated with NAFLD in middle-aged and elderly Chinese.