沙格列汀对老年2型糖尿病中性粒细胞／淋巴细胞比值的影响

Effect of saxagliptin on peripheral blood neutrophil-to-lymphoeyte ratio in elder patients with type 2 diabetes mellitus

观察沙格列汀对老年2型糖尿病患者中性粒细胞／淋巴细胞比值（NLR）的影响。选取110例新诊断的老年2型糖尿病患者，分为沙格列汀治疗组（SG，安立泽，阿斯利康，n=55）和瑞格列奈对照组（RG，孚来迪，江苏豪森，n=55），2组治疗时间均为12周。治疗前SG组、RG组血清NLR水平均明显升高，差异没有统计学意义（P〉0．05），治疗后2组NLR水平下降，sG组下降更为明显（P〈0．05）。

To explore the clinical effect of saxagliptin on release of peripheral blood neutrophil-tolymphocyte ratio（NLR） in elder patients with type 2 diabetes mellitus. A total of 110 newly-diagnosed elder patients with type 2 diabetes were assigned into 2 groups （ both n = 55 ）. Trial group was treated with exercise-diet therapy and saxagliptin at 5 mg/d（ SG group） , while control group with exercise-diet therapy and repaglinide （RG group）. NLR were evaluated in both groups before treatment without significant difference （ P〉0.05 ）. After 12 weeks＇ treatment, NLR were both lowered. Decrease of NLR in SG group was more significant than that of RG group（ P〈0.05 ）.