Kiss1／Kiss1受体系统与生殖功能的研究进展

Progress in research of KISS1/KISS1R system and reproductive function

Kiss1基因编码Kisspeptins，是一种细胞间信号肽，其相应的受体为Kiss1R。最初的研究发现Kiss1／Kiss1R系统具有抑制肿瘤转移的作用，越来越多的证据表明，其可作用于下丘脑-垂体-性腺轴，是青春期启动和进展的关键，在生殖的神经内分泌调节中扮演重要角色。本文就Kiss1／Kiss1R系统的发现、诱导的细胞内信号转导通路、对下丘脑-垂体-性腺轴的作用、调节机制及其临床应用进行综述。

Kiss1 gene encodes Kisspeptins, an intercellular signal peptide whose corresponding receptor is Kissl R. The initial study found that the Kiss1/Kiss1 R system has the effect on inhibiting tumor metastasis. More and more evidence suggests that it can act on the hypothalamic-pituitary-gonadal （HPG） axis and is the key to puberty initiation and progression. It plays an important role in the neuroendocrine regulation of reproduction. In this paper, we reviewed the studies on Kissl/Kissl R system, its intracellular signal transduction pathway, role on HPG axis, and clinical application.