还原型谷胱甘肽辅助思密达混合液治疗宫颈癌放射性直肠炎的疗效观察

Efficacy of GSH adjuvant therapy combined with mixed solution Smecta for radiation-induced proctitis in patients with cervical cancer

目的探讨还原型谷胱甘肽(GSH)辅助思密达混合液治疗宫颈癌放射性直肠炎的效果及对患者外周血白细胞介素-8(IL-8)和k基因结合核因(NF-κB)的影响。方法选取2014年1月至2016年7月间建湖县人民医院收治的120例宫颈癌放射性直肠炎患者,采用随机数表法分为观察组和对照组,每组60例。观察组患者在思密达混合液灌肠治疗基础上联合GSH辅助治疗,对照组患者采用思密达混合液灌肠治疗,对比两组患者临床疗效及治疗前后IL-8和NF-κB水平及生活质量。结果观察组患者的治疗有效率为85.0%,高于对照组的53.3%,差异有统计学意义(P<0.05)。两组患者治疗前肿瘤坏死因子-α(TNF-α)、IL-8和NF-κB表达水平比较,差异无统计学意义(P>0.05);治疗后两组患者TNF-α、IL-8和NF-κB表达水平均显著下降,且观察组患者表达水平均低于对照组患者,差异均有统计学意义(均P<0.05)。治疗前两组患者生活质量中的日常生活、社会活动、抑郁心理和焦虑心理评分比较,差异无统计学意义(P>0.05);治疗后两组患者生活质量各项评分均降低,其中,观察组评分低于对照组,差异均有统计学意义(均P<0.05)。结论 GSH辅助思密达混合液治疗可显著降低宫颈癌放射性直肠炎患者外周血中IL-8和NF-κB水平,提高治疗效果和生活质量。

Objective To investigate the efficacy of GSH supplementation mixed solution Smecta for cervical cancer associated radiation proctitis and the effect on interleukin-8（ IL-8） and nuclear factor-kgene binding（ NF-κB） in peripheral blood of patients with cervical cancer complicated with radiation-induced proctitis. Methods A total of 120 patients with cervical cancer complicated with radiation-induced proctitis treated at Jianhu County People＇s Hospital from January 2014 to July 2016 were randomly divided into an observation group and a control group with 60 patients in each group according to the digital random table method. Patients in the observation group were given enema therapy with mixed solution Smecta combined with adjuvant therapy and the control group was given enema therapy with mixed solution Smecta. The levels of IL-8 and NF-κB and quality of life were compared between the two groups before and after the treatment. Results The efficacy rate in the observation group（ 85. 5%） was significantly higher than in the control group（ 53. 3%）（ P〈0. 05）. There was no significant difference in the expression levels of tumor necrosis factor-α（ TNF）-α,IL-8 and NF-κB between the two groups before the treatment（ P〈0. 05）. After the treatment,the levels of the above three indexes significantly decreased with the observation group lower than the control group（ all P〈0. 05）. There were no significant differences in daily life,social activity,and the scores of depression and anxiety between the two groups before the treatment（ P〈0. 05）. After the treatment,the scores of quality of life significantly improved with the observation group significantly lower than the control group（ P〈0. 05）. Conclusion GSH adjuvant therapy combined with mixed solution can significantly reduce the levels of IL-8 and NF-κB in peripheral blood of patients with cervical cancer complicated with radiation-induced proctitis,which improves the treatment efficacy and quality of life.