七叶皂苷钠联合甘露醇治疗脑出血临床疗效探讨

Discussion on clinical efficacy of sodium aescinate combined with mannitol in the treatment of cerebral hemorrhage

目的分析七叶皂苷钠联合甘露醇治疗脑出血的临床疗效。方法 86例脑出血患者,随机分为观察组与对照组,各43例。两组除了给予常规的基础治疗外,对照组给予甘露醇静脉滴注,观察组在对照组的基础上给予七叶皂苷钠静脉滴注,比较两组患者临床疗效、治疗前后神经功能缺损评分、血肿量以及不良反应情况。结果治疗后,观察组患者临床治疗总有效率为95.3%,明显高于对照组的69.8%,差异具有统计学意义(P<0.05)。治疗前,两组患者神经功能缺损评分及血肿量比较差异无统计学意义(P>0.05);治疗后,观察组患者神经功能缺损评分及血肿量均明显低于对照组,差异具有统计学意义(P<0.05)。在治疗期间观察组患者面红1例、头晕3例,不良反应发生率为9.3%(4/43);对照组恶心1例、头晕2例,不良反应发生率为7.0%(3/43);两组患者不良反应发生率比较差异无统计学意义(χ2=0.16,P>0.05)。结论给予脑出血患者七叶皂苷钠联合甘露醇治疗,对于改善患者的预后具有明显的意义。

Objective To analyze the clinical efficacy of sodium aescinate combined with mannitol in the treatment of cerebral hemorrhage. Methods A total of 86 cerebral hemorrhage patients were randomly divided into observation group and control group, with 43 cases in each group. Both groups received conventional basic treatment, and the control group also received intravenous infusion of mannitol. The observation group received intravenous infusion of sodium aescinate on the basis of the control group. Comparison were made on clinical efficacy, neurological deficit score before and after treatment, hematoma volume and adverse reactions between two groups. Results After treatment, the observation group had obviously higher total effective rate of clinical treatment as 95.3% than 69.8% in the control group, and the difference was statistically significant（P〈0.05）. Before treatment, both groups had no statistically significant difference in neurological deficit score and hematoma volume（P〈0.05）. After treatment, the observation group had obviously lower neurological deficit score and hematoma volume than the control group, and the difference was statistically significant（P〈0.05）. During treatment, the observation group had 1 case of red face, 3 cases of dizziness, with incidence of adverse reactions as 9.3%（4/43）, while the control group had 1 case of nausea and 2 cases of dizziness, with incidence of adverse reactions as 7.0%（3/43）. Both groups had no statistically significant difference in incidence of adverse reactions（χ2=0.16, P〈0.05）. Conclusion Combination of sodium aescinate and mannitol shows obvious significance in improving prognosis of patients with cerebral hemorrhage.