急性脑损伤人体血清二氧化碳结合力变化的临床研究

Clinical study on changes of serum carbon dioxide combining power in body with acute brain injury

目的研究急性脑损伤人体血清二氧化碳结合力(CO_2CP)的改变。方法 99例急性自发性脑出血患者作为实验1组,81例急性创伤性颅脑损伤患者作为实验2组[根据格拉斯哥昏迷评分(GCS)分为A组(39例)与B组(42例)],31例健康人员作为对照组,采用酶法测定各组研究对象血清CO_2CP浓度,并进行组间比较。结果实验1组CO_2CP浓度与对照组比较差异无统计学意义(P>0.05);实验2组CO_2CP浓度(22.4±3.5)mmol/L明显低于对照组(25.0±1.4)mmol/L及实验1组(24.8±2.8)mmol/L,差异均具有统计学意义(P<0.05)。B组入院时CO_2CP浓度(21.5±3.8)mmol/L明显低于A组(23.5±3.0)mmol/L,差异具有统计学意义(P<0.05)。结论急性创伤性颅脑损伤可通过CO_2CP下降引起继发性脑损伤。

Objective To study the changes of serum carbon dioxide combining power（CO2 CP） in body with acute brain injury. Methods There were 99 patients with acute spontaneous intracerebral hemorrhage as experiment group 1, 81 patients with acute traumatic brain injury as experimental group 2 [divided by Glasgow coma scale（GCS） into group A（39 cases） and group B（42 cases）], and 31 healthy cases as control group. Serum CO2 CP concentrations were measured by enzyme method and compared between groups. Results Experimental group 1 had no statistically significant difference in CO2 CP concentrations comparing with the control group（P〉0.05）. The experimental group 2 had obviously lower CO2 CP concentrations as（22.4±3.5） mmol/L than（25.0±1.4） mmol/L in the control group and（24.8±2.8） mmol/L in experimental group 1. Their difference was statistically significant（P〈0.05）. Group B had obviously lower CO2 CP concentrations at admission as（21.5±3.8） mmol/L than（23.5±3.0） mmol/L in group A, and the difference was statistically significant（P〈0.05）. Conclusion Acute traumatic brain injury may cause secondary brain injury through CO2 CP decline.