氯吡格雷联合阿司匹林治疗脑梗死的疗效观察

Efficacy observation on clopidogrel combined with aspirin in the treatment of cerebral infarction

目的观察氯吡格雷联合阿司匹林治疗脑梗死的临床效果。方法 100例脑梗死患者,按治疗方式不同分为对照组(45例)和观察组(55例)。对照组给予阿司匹林治疗,观察组在对照组基础联合氯吡格雷治疗,比较两组临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分、超敏C反应蛋白(hs-CRP)含量及不良反应情况。结果观察组临床总有效率为85.45%,明显高于对照组的66.67%,差异有统计学意义(P<0.05)。观察组NIHSS评分低于对照组,hs-CRP含量少于对照组,差异有统计学意义(P<0.05)。观察组出现皮肤淤点1例、胃肠道不适2例、牙龈轻微出血1例;对照组出现皮肤淤点、胃肠道不适各1例;未予特殊处理均自行好转。结论脑梗死采用氯吡格雷联合阿司匹林进行治疗,可有效减轻患者神经功能缺损,降低hs-CRP含量,缓解炎症,促进疗效提高,具有一定的临床应用与研究价值。

Objective To observe the clinical effect of clopidogrel combined with aspirin in the treatment of cerebral infarction. Methods A total of 100 cerebral infarction patients were divided by different treatment methods into control group（45 cases） and observation group（55 cases）. The control group was treated with aspirin, and the observation group was treated with clopidogrel on the basis of the control group. Comparison were made on clinical efficacy, National Institute of Health Stroke scale（NIHSS） score, hypersensitivity C reactive protein（hsCRP） content and adverse reactions in two groups. Results The observation group had obviously higher clinical total effective rate as 85.45% than 66.67% in the control group, and the difference was statistically significant（P〈0.05）. The observation group had lower NIHSS score than the control group, and less hs-CRP content than the control group. Their difference was statistically significant（P〈0.05）. The observation group had 1 case of skin petechiae, 2 cases of gastrointestinal discomfort and 1 case of slight gingival bleeding, while the control group had 1 case of skin petechiae, 1 case of gastrointestinal discomfort. Patients self-improved without special treatment. Conclusion Combination of clopidogrel and aspirin can effectively reduce the neurological impairment of patients with cerebral infarction, reduce the content of hs-CRP, relieve inflammation, and promote efficacy. It has certain clinical application and research value.