脑心通胶囊联合尿激酶溶栓治疗急性脑梗死的临床疗效及其对血清中VEGF、Ang-2的影响

Clinical Effect of Naoxintong Capsule and Urokinase Thrombolysis on Acute Cerebral Infarction and Its Effect on Serum VEGF and Ang-2

目的分析并探讨脑心通胶囊联合尿激酶溶栓治疗急性脑梗死的临床疗效及其对血清中VEGF、Ang-2的影响。方法选取2014年5月-2016年5月在我院接受治疗的急性脑梗死患者160例,将其随机分为治疗组与对照组,每组80例。治疗组采取脑心通胶囊联合尿激酶溶栓治疗,对照组则仅给予尿激酶溶栓治疗。观察两组临床效果及血清血管内皮生长因子(VEGF)和血管生成素-2(Ang-2)的变化。结果治疗组的治疗总有效率为93.75%,对照组为72.50%,两组总有效率比较,差异有统计学意义(P<0.05)。两组患者治疗后VEGF和Ang-2与治疗前比较均有显著提高(P<0.05),且治疗组与对照组比较,VEGF和Ang-2升高更明显(P<0.05)。结论脑心通胶囊联合尿激酶溶栓治疗急性脑梗死临床效果显著,这暗示出联合脑心通胶囊溶栓效果更佳的机制可能与新生血管及侧支循环相关,临床上表现为VEGF和Ang-2上升。

Objective To analyze the effect of Naoxintong capsule and urokinase thrombolysis on acute cerebral infarction and its effect on serum VEGF and Ang-2. Method 160 patients with acute cerebral infarction in our hospital from May 2014 to May 2016 were randomly divided into observation group and control group with 80 cases in each group. The observation group was treated with Naoxintong capsule and urokinase. The control group was given with urokinase. The changes of serum vascular endothelial growth factor（VEGF） and angiopoietin-2（Ang-2） were observed. Results The total effective rate was 93. 75% in the observation group and 72. 50% in the control group. The total effective rate of the two groups was statistically significant（P〈0. 05）. Compared with the before treatment,the VEGF and Ang-2 were significantly higher in the two groups（P〈0. 05）,and the observation group VEGF and Ang-2 increased more significantly（P〈0. 05）. Conclusion Naoxintong capsule and urokinase thrombolysis in the treatment of acute cerebral infarction clinical effect is significant,which suggested that the better thrombolytic effect of Naoxintong capsule may be relate to collateral circulationand the clinical manifestations are VEGF and Ang-2 increase.