基于阳极阻滞技术的骶神经根电刺激器设计与制作

Design and fabrication of sacral nerve root electric stimulator based on anodal block technique

目的为了辅助脊髓损伤后神经源性膀胱功能恢复,设计了基于阳极阻滞技术的骶神经根电刺激器。方法通过将阳极阻滞与骶神经根电刺激技术相融合,使电刺激骶神经前根时产生的动作电位可以选择性在副交感神经中传导,从而引起膀胱排空更接近于正常生理性排空。此外,通过采用三极电极作为电极,从而最大限度地避免刺激电流对周围组织干扰。系统设计按照电路功能模块划分为升压电路、脉冲信号放大电路、主控制电路、人机交互电路和外部通讯电路。结果测试结果表明,系统脉冲宽度范围为100~500μs,脉冲频率为3~20 Hz,脉冲工作时间为3~20 s,间歇时间为5~40 s。结论该刺激器能够满足尿动力学实验所确定的阳极阻滞电刺激参数指标要求,从而为下尿路障碍患者提供一种新的治疗方案。

Objective To design an electric stimulator about sacral nerve root based anodal block technique for recovery neuro-genic bladder ability after spinal cord injury. Methods The selective conduction of action potential in the parasympathetic nerve was realized by the technical integration of anodal block and sacral nerve root stimulation to make bladder emptying more close to the normal physiological act. Three-pole electrode was adopted in the design, the stimulation current was totally prevented from interfering with the surrounding tissue. The system design was divided into boost circuit, pulse signal amplifying circuit, main control circuit, human-computer interaction circuit and external communication circuit. Results The test results showed that the pulse width was 100-500 μs, pulse frequency was 3-20 Hz, pulse operating time was 3-20 seconds, and intermittent time was5-40 seconds. Conclusion It is demonstrated that the parameters of the stimulator meet the requirements of anodal block elec-tric stimulator for urodynamic experiments, and provides a new treatment for patients with lower urinary tract obstruction.