氟西汀和帕罗西汀改善青少年抑郁症患者认知功能比较研究

Comparative Study of Fluoxetine and Paroxetine in Improving Cognitive Function in Adolescent Patients with Depression

目的比较氟西汀和帕罗西汀对改善青少年抑郁症患者认知功能的疗效。方法选取重庆市精神卫生中心2013年至2015年收治的青少年抑郁患者50例,随机分为氟西汀组和帕罗西汀组,各25例,于治疗前和治疗8周后采用汉密尔顿抑郁量表24项(HAMD-24)评定病情严重程度,用威斯康星卡片分类测验(WCST)和临床记忆量表(CMS)分别评定执行功能和记忆功能。结果两组患者治疗后组内HAMD-24总分、WCST和CMS各因子较治疗前差异均有统计学意义(P<0.01);治疗前后,两组组间HAMD-24总分、CMS和WCST各因子的总测验数、正确应答数、错误应答数的差异无统计学意义(P>0.05),WCST的完成分类数差异有统计学意义(P<0.05)。结论氟西汀和帕罗西汀均能改善青少年抑郁症患者的症状和认知功能,但帕罗西汀优于氟西汀。

Objective To compare the clinical efficacy of fluoxetine and paroxetine in the treatment of cognitive function in adolescent patients with depression. Methods Totally 50 adolescent patients with depression in Chongqing Mental Health Center from 2013 to 2015 were selected and randomly divided into the fluoxetine group and the paroxetine group, 25 cases in each group. Before treatment and after 8 weeks of treatment, the severity of the disease in two groups was assessed by the Hamilton Depression Scale 24 （ HAMD-24 ） , the executive and memory functions of two groups were assessed by the Wisconsin Card Sorting Test （ WCST ） and the clinical memory scale （CMS） . Results Compare with before treatment, the total scores of HAMD-24, the factors of WCST and CMS in the two groups were significantly different （ P 0. 05 ） . There were statistical differences in the number of completed categories of the WCST between the two groups （ P 〈 0. 05 ） . Conclusion Fluoxetine and paroxetine can im-prove symptoms and cognitive function in adolescent patients with depression, but paroxetine is superior to fluoxetine.