艾司西酞普兰与帕罗西汀治疗老年性抑郁症疗效对比

Comparative Effect of Escitalopram and Paroxetine in Treating Senile Depression

目的对比艾司西酞普兰与帕罗西汀治疗老年性抑郁症的疗效。方法选取2016年7月至2017年7月接诊的老年性抑郁症患者116例,按入院顺序编号随机分为两组,各58例。观察组患者给予艾司西酞普兰干预治疗,对照组患者给予帕罗西汀干预治疗。结果治疗1周后,观察组抑郁程度改善情况明显好于对照组,观察组抑郁自评量表(SDS)评分为(42.31±4.05)分,明显低于对照组的(49.25±4.21)分(P<0.05);观察组患者出现不良反应8例(13.80%),显著少于对照组的27例(46.55%),组间差异明显(P<0.05)。结论艾司西酞普兰治疗老年性抑郁症的疗效明显优于帕罗西汀,可最大程度地减少不良反应,值得推广。

Objective To compare the clinical effect of escitalopram and paroxetine in treating senile depression. Methods Totally 116 patients with senile depression in our hospital from July 2016 to July 2017 were selected and randomly divided into two groups according to the order of admission, 58 cases in each group. The observation group was given escitalopram, while the control group was given paroxetine. Results After 1 week of treatment, the improvement of depression in the observation group was significantly better than that in the control group, the SDS score of the observation group was （ 42. 31 ± 4. 05 ） points, which was significantly lower than （ 49. 25 ± 4. 21 ） points of the control group （ P 〈 0. 05 ） . There were 8 cases （ 13. 80% ） of adverse reactions in the observation group, which were significantly less than 27 cases （ 46. 55% ） in the control group, the difference between the two groups was obvious （ P 〈 0. 05 ） . Conclusion The efficacy of escitalopram in the treatment of senile depression is significantly better than that of paroxe-tine, it can furthest reduce the adverse reactions, and which is worthy of promotion.