1例利奈唑胺致药源性血小板减少症的药学监护

Pharmaceutical Care of 1 Patient with Linezolid-Induced Thrombocytopenia

目的探讨临床药师在利奈唑胺致药源性血小板减少症个体化用药和用药监护中的作用。方法分析1例肺部感染患者发生药源性血小板减少症的临床资料,判断可疑药物与不良反应之间的关系,总结实施药学监护的要点。结果血小板减少症是利奈唑胺所致严重药品不良反应,其高危因素有高龄、治疗周期长、联用3种以上抗菌药物及肾功能不全等。结论临床药师参与药学监护,可以促进临床更加规范、合理地用药,更好地体现个体化用药及用药监护。

Objective To investigate the role of clinical pharmacists in individualized drug use and medication monitoring of linezolid-induced thrombocytopenia. Methods The clinical data of 1 patient with pulmonary infection and drug-induced thrombocytopenia was analyzed, in order to judge the relationship between suspicious drugs and adverse drug reactions, and summarize the main points of implementation of pharmaceutical care. Results Thrombocytopenia was the severe adverse drug reaction induced by linezolid. The high risk factors were advanced age, long-term treatment, combined use of more than 3 kinds of antibiotics and renal insufficiency. Conclusion The clinical pharmacists participate in pharmaceutical care can promote more standardized and rational drug use in clinical, and better reflect individualized medication and medication monitoring.