动脉钙化发生机制的研究进展

The research progress of the mechanism of arterial calcification

动脉钙化常见于动脉粥样硬化、糖尿病、老年人及慢性肾脏病患者,是导致心血管疾病发生发展和致死的重要原因。目前认为,动脉钙化是一种类似于骨形成的主动调控过程,其中血管平滑肌细胞(VSMCs)是动脉钙化的细胞学基础。然而,动脉钙化的确切机制尚不清楚,多种因素如C反应蛋白(CRP)、骨形成蛋白(BMPs)、核苷酸结合寡聚化结构域样受体3(NLRP3)以及骨保护素(OPG)等都影响其进程。笔者简要综述了炎症、细胞因子和相关免疫与动脉钙化的关系。

Vascular calcification is prevalent in patients with atherosclerosis, old age, diabetesmellitus,and chronic kidney diseases. It is highly associated with increased morbidity and mortality ofcardiovascular diseases.At present,arterial calcification is a kind of active regulation process similar to boneformation,in which vascular smooth muscle cells are the cytological basis.However,the exact mechanism ofarterial calcification is not clear,a variety of factors such as C-reactive protein,bone morphogenetic proteins,NLRP3 inflammatory body and osteoprotegerin and so on can affect its progress.This paper briefly reviews therelationship among inflammation,cytokines and related immunity with arterial calcification.