生酮饮食对肥胖影响的研究

Ketogenic diet and obesity

目的探讨生酮减脂对体重、体脂、内脏脂肪等的作用。方法本研究通过募集符合入组标准的减脂人士,根据生酮饮食的基本原理,对减脂人士进行饮食管理,采用"柔性生酮"的方式,不经过禁食过程,直接切换为生酮饮食。生酮饮食三大营养素配比为可利用碳水化合物12g左右,蛋白质1g/kg体重,其他以脂肪补充,至总供给能量约等于基础代谢,除富含中链脂肪酸的椰子油外,脂肪供应种类不限。定期人体成分分析动态观察体重、骨骼肌重量、体脂率、体脂等,定期进行人体学测量,计算腰臀比。结果减脂人士从第一周开始即出现体重的明显下降,4周累计下降(3.99±2.29)kg,体脂保持持续下降和生酮减脂持续时间正相关:y=1.32423+0.37536~*x,R^2=0.81966。同时生酮减脂能够有效降低减脂人士的腰臀比(y=0.016+0.00476~*x,R^2=0.61009)。结论生酮减脂对体脂和腰臀比减少效果明显,且和持续时间正相关。生酮治疗已有近百年的临床应用历史,适应证从癫痫逐步扩展到体重管理,肿瘤等多个领域。

Objective To investigate the effect of ketogenic fat on body weight, body fat and visceral fat. Methods In this study, we recruited several volunteers whose meet the standard of clinical studies. According to the basic principle of the ketogenic diet, we manage diets of volunteers, measure body weight, skeletal muscle weight, body fat by body composition analysis, calculate waist hip ratio based on anthropometry data at regular intervals. Results From the the first week, body weight of volunteers has begun declined, accumulating weight reduction is（3.99±2.29）kg in 4 weeks, body fat reduction continued decline during ketogenic diet period, shows positively relationship： y=1.32423 0.37536~＊x, R^2=0.81966. At the same time, ketogenic diets also can effectively reduce hip ratio dieters（y=0.016 0.00476~＊x, R^2=0.61009）. Conclusions the ketogenic diets has obviously affect on body fat reduction and waist to hip ratio decreased, and has positive correlation to time of duration. Ketogenic diet used in clinical treatment has lasted nearly a hundred years, its indications from epilepsy extended to weight reduction, tumor therapy, and so on.