噻托溴铵、沙美特罗/氟替卡松(大剂量)对支气管哮喘合并慢性阻塞性肺疾病(稳定期)的临床观察

Clinical observation of tiotropium bromide,salmeterol/fluticasone(high dose) in the treatment of bronchial asthma with chronic obstructive pulmonary disease(stable)

目的:探讨噻托溴铵、沙美特罗/氟替卡松(大剂量)对支气管哮喘合并慢性阻塞性肺疾病(稳定期)的效果。方法:收治支气管哮喘合并慢性阻塞性肺疾病(稳定期)患者40例,分为对照组和观察组,各20例。对照组用异丙托胺溶液+沙美特罗+氟替卡松(大剂量)治疗,观察组用噻托溴铵干粉吸入剂+沙美特罗+氟替卡松(大剂量)治疗。结果:观察组FEV_1、6MWT、急性发作次数及其间隔时间、生活质量评分等均优于对照组(P<0.05)。结论:噻托溴铵干粉吸入剂+沙美特罗+氟替卡松(大剂量)治疗支气管哮喘合并慢性阻塞性肺疾病(稳定期)患者的效果显著,可充分改善患者FEV_1、6MWT,并有效减少患者急性发作次数并延长发作间隔时间。

Objective：To evaluate the efficacy of tiotropium,salmeterol/fluticasone（high-dose） in the treatment of bronchial asthma with chronic obstructive pulmonary disease（stable）.Methods：40 patients with bronchial asthma complicated with chronic obstructive pulmonary disease（stable） were selected.They were divided into the control group and the observation group with 20 cases in each.The control group was treated with ipratropium amine solution ＋ salmeterol ＋ fluticasone（high dose）,and the observation group was treated with tiotropium bromide inhalation＋salmeterol plus fluticasone（high dose）.Results：The FEV_1,6 MWT,acute attack,interval time and number,quality of life of the observation group were better than those of the control group（P〈0.05）.Conclusion：The effect of tiotropium bromide inhalation ＋ salmeterol plus fluticasone（high dose） in the treatment of bronchial asthma complicated with chronic obstructive pulmonary disease（stable stage） is significant,which can improve patients with FEV_1 and 6 MWT,and reduce the number and time of interval effectively in patients with acute attack.