针灸治疗脑出血急性期的Meta分析

Acupuncture for Acute Cerebral Hemorrhage:A Systematic Review and Meta-analysis

目的:系统评价针灸治疗脑出血急性期的临床疗效,以期为临床提供循证医学依据。方法:从多个数据库中检索针灸治疗脑出血急性期的随机对照文献,由两名研究者根据纳入和排除标准,独立筛选适合的文献,提取资料并对纳入的研究进行偏倚风险评估。采用统计软件Review Manager 5.3进行Meta分析。结果:共纳入14篇文献,累计病例985例。Meta分析结果显示,7篇文献的总有效率OR=2.97,95%CI为[1.86,4.74],合并效应量检验Z=4.56,P<0.000 01;8篇文献的神经功能缺损积分比较MD值为-2.27,95%CI为[-2.83,-1.71],合并效应量检验Z=7.96,P<0.000 01。治疗组和对照组疗效比较差异有统计学意义(P<0.01)。漏斗图显示发表偏倚可能性较小。结论:针灸治疗脑出血急性期疗效肯定,但鉴于可供纳入研究文献较少,质量较低,尚需更多高质量的研究加以验证。

Objective：To evaluate the clinical efficacy of acupuncture and moxibustion in the treatment of acute cere- bral hemorrhage in order to provide evidence - based medicine for clinic. Methods ： A randomized controlled literature on the acute phase of cerebral hemorrhage was obtained from multiple databases. Two researchers selected the appropriate literature independently according to the inclusion and exclusion criteria, and extracted the information and evaluated the bias risk. Meta - analysis was performed by using the statistical software Review Manager 5.3. Results ： A total of 14 arti- cles were included and 985 cases were accumulated. Meta - analysis showed that the total effective rate of the seven liter- atures was OR =2. 97, 95% CI [ 1.86,4. 74], the combined effect test Z =4. 56, P 〈0. 000 01 ; 8 points of neurological deficit score MD = - 2. 27, 95% CI [ - 2. 83, - 1.71 ], the combined effect test Z = 7.96, P 〈 0. 000 01. The differ- ence between the treatment group and the control group was statistically significant （ P 〈 O. O1 ）. The funnel graph shows that the publication bias is less likely. Conclusion： Acupuncture and moxibustion treatment of acute cerebral hemorrhage was positive, but in view of the need for inclusion in the literature, the quality is low and still need more high - quality research to be verified.