王今达教授“菌毒炎并治”脓毒症的实验基础与临床实践总结

Experimental basis and clinical practice of ＂bacterial poison and cure＂ sepsis

自20世纪70年代起，天津市第一中心医院王今达教授的研究团队开始应用活血化瘀法抢救危重患者。随着对脓毒症认识的不断深入，提出了＂菌毒炎并治＂理论，并使用活血化瘀药物血必净注射液拮抗内毒素及炎性介质治疗脓毒症，取得了一定的临床疗效。但近年来国内外对脓毒症的治疗进展缓慢，我们重温20世纪80年代末的一系列动物实验研究发现，微循环的微小血栓形成及机体凝血功能紊乱在一般感染向脓毒症过渡中扮演着更为重要的角色，结合血必净注射液被越来越多的临床实践证实有效，血瘀证及活血化瘀法在脓毒症中的重要地位必须再次予以重视。

Since the 20th century, research team of Professor Wang Jinda in the Tianjin First Central Hospital has been using blood circulation drugs to rescue critically ill patients for 70 years. With the deepening of the understanding of sepsis, put forward the ＂bacteria and inflammation and governance＂ theory, and the use of blood circulation drugs Xuebijing injection with anti-endotoxin and inflammatory mediators effect in the treatment of sepsis, some clinical efficacy has been found. However, in recent years, the progress of treatment of sepsis at home and abroad is slow, we review a series of animal experiments since the late of 1980s, and found that small thrombosis in the microcirculation and coagulation disorders play a more important role in the development of local infection to sepsis transition. Treatment combined with Xuebijing injection is proved effective with more and more clinical practice, so the important status of blood stasis and blood circulation method in sepsis must be paid attention to again.