卡培他滨单药或联合方案治疗乳腺癌骨转移的临床疗效观察

Clinical Efficacy of Capecitabine Monotherapy or Combination with Chemotherapy in the Treatment of Breast Cancer with Bone Metastasis

目的探讨卡培他滨单药或联合伊班膦酸钠方案治疗乳腺癌骨转移的临床疗效。方法选择乳腺癌骨转移患者106例作为研究对象,根据随机信封抽签原则分为观察组与对照组各53例,对照组给予卡培他滨单药治疗,观察组在对照组治疗的基础上联用伊班膦酸钠治疗。结果治疗后观察组与对照组总有效率分别为86.8%和69.8%,观察组总有效率明显高于对照组(P<0.05)。观察组随访1年、2年、3年的生存率分别为90.6%、77.4%和49.1%,都明显高于对照组的79.2%、50.9%和20.8%(P<0.05)。治疗后观察组与对照组的骨痛NRS评分分别为(1.43±0.84)分和(2.53±1.21)分,都明显低于治疗前的(6.93±2.01)分和(6.91±2.13)分(P<0.05),治疗后观察组的骨痛NRS评分也明显低于对照组(P<0.05)。结论相对于卡培他滨单药方案,卡培他滨联合伊班膦酸钠方案治疗乳腺癌骨转移能有效降低骨痛,提高治疗疗效,从而延长患者的生存期,有很好的应用价值。

Objective To investigate the clinical efficacy of capecitabine monotherapy or combination with ibandronate in the treatment of breast cancer with bone metastasis.Methods 106 cases of breast cancer with bone metastasis were selected as the research object,all the cases were divided into the observation group and the control group,with 53 cases in each group,according to the random draw envelope,the control group was given capecitabine monotherapy,the observation group was given the ibandronate treatment based on the the control group.Results After treatment,the total effective rates of the observation group and the control group were 86.8% and 69.8%,respectively.The total effective rate of the observation group was significantly higher than that of the control group（P 0.05）.1-,2-,3-year survival rates of the observation group were 90.6%,77.4% and49.1%,respectively,which were significantly higher than those of the control group of 79.2%,50.9%,and 20.8%（P 0.05）.After treatment,the NRS pain scores in the observation group and the control group were 1.43 ± 0.84 points and 2.53 ± 1.21 points,which were significantly lower than those before treatment of 6.93 ± 2.01 points and 6.91 ± 2.13 points（P 0.05）,the NRS pain score in the observation group after treatment was significantly lower than the control group（P 0.05）.Conclusion Compared with capecitabine monotherapy,capecitabine combined with ibandronate in the treatment of breast cancer with bone metastasis can effectively reduce bone pain,improve curative effect,so as to prolong the survival time of patients,and it has good application values.