参芪扶正注射液对急性淋巴细胞白血病病人骨髓造血功能和免疫功能的影响

Effect of Shenqifuzheng injection on bone marrow hematopoietic and immune function in patients with acute lymphoblastic leukemia

目的:观察分析参芪扶正注射液对急性淋巴细胞白血病(ALL)病人化疗前后骨髓造血功能和免疫功能的影响。方法:选择ALL病人60例,随机分为观察组和对照组,每组30例,2组均接受化疗,观察组在此基础上加用参芪扶正注射液,观察2组病人治疗前后血常规、T细胞亚群和B细胞亚群的变化情况。结果:经治疗,观察组有效率90.00%,对照组有效率86.67%,差异无统计学意义(P>0.05)。在化疗2周和化疗后1周,观察组病人的白细胞、红细胞、血红蛋白均优于对照组(P<0.05~P<0.01),观察组病人化疗后T淋巴细胞亚群CD3^+、CD4^+、CD4^+/CD8^+比值均优于对照组(P<0.05);2组病人治疗后血小板、B淋巴细胞CD3^-CD19^+水平差异均无统计学意义(P>0.05)。结论:临床上化疗基础上联合应用参芪扶正注射液辅助治疗ALL,可以有效改善病人因化疗而出现的骨髓抑制,提高其细胞免疫功能,促进病人恢复。

ObjectiveTo investigate the effects of Shenqifuzheng injection（SFI） on bone marrow hematopoietic and immune functionin patients with acute lymphoblastic leukemia （ ALL） before and after chemotherapy. Methods： Sixty ALL patients were randomlydivided into the observation group and control group （30 cases each group）. Two groups were treated with chemotherapy, and theobservation group were additionally treated with SFI. The blood routine,and T and B lymphocyte subsets in two groups were observedbefore and after treatment. Results：The effective rate in observation group and control group were 90%,and 86. 67%,respectively,andthe difference of which was not statistically significant （ P 〉 0. 05 ）. During two weeks of chemotherapy and after 1 week ofchemotherapy,the counts of white blood cell and red blood cell,and hemoglobin level in observation group were significantly higher thanthose in control group（P 〈 0. 05 ~ P 〈 0. 0）,and the ratios of CD3 ＋,CD4 ＋and CD4 ＋/ CD8 ＋in observation group after chemotherapywere better than those in control group（P 〈 0. 05）. The differences of the levels of blood platelet and CD3 -CD19 ＋between two groupswere not statistically significant（P 〉 0. 05）. Conclusions：The treatment of ALL with SFI can effectively improve the myelosuppressioninduced by chemotherapy,enhance the immunologic function,and promote the recovery of patients after chemotherapy.