帕金森病人血清分化型胚胎软骨表达基因1和肝X受体β水平的相关性研究

The levels of DEC1 and LXR β in Parkinson's disease and its correlation

目的:探讨帕金森病(PD)病人血清中分化型胚胎软骨表达基因1(DEC1)和肝X受体β(LXRβ)水平及二者相关性。方法:选择PD病人50例(PD组),选择同期健康人群50名为对照(对照组)。检测2组受试者血清DEC1、LXRβ水平。结果:PD组血清DEC1水平明显高于对照组(P<0.01),LXRβ水平明显低于对照组(P<0.01)。不同性别的PD病人DEC1和LXRβ水平差异均无统计学意义(P>0.05);年龄≥60岁PD病人的LXRβ水平低于<60岁者(P<0.05);有认知功能障碍的PD病人DEC1和LXRβ水平分别明显高于和低于无认知障碍者(P<0.01);随病情分期加重,PD病人的DEC1水平逐渐升高,LXRβ水平逐渐降低(P<0.05~P<0.01)。PD病人血清DEC1水平与LXRβ水平呈负相关关系(r=-0.326,P<0.05)。结论:PD病人血清DEC1与LXRβ水平呈负相关关系,二者与PD的发病及病情进展有关。

ObjectiveTo explore the serum levels of differentiated embryonic chondrocyte expression gene 1 （DEC1） and liver Xreceptor β（LXRβ） in Parkinson忆s disease（PD）,and its correlation. Methods：Fifty PD patients and 50 healthy people were dividedinto the PD group and control group,respectively. The serum levels of DEC1 and LXRβ in two groups were tested. Results：The serumlevels of DEC1 and LXRβ in PD group were significantly higher and lower than that in control group,respectively（P 〈 0. 01）. Thedifferences of serum levels of DEC1 and LXRβ between different genders of PD group were not statistically significant（P 〉 0. 05）. Theserum level of LXRβ in more than or equal to 60 years old PD patients was lower than that in less than 60 years old PD patients（P 〈0. 05）. The serum levels of DEC1 and LXRβ in PD patients with cognitive dysfunction were significantly higher and lower than those inPD patients without cognitive dysfunction,respectively（P 〈 0. 01）. With the deterioration of PD patients,the serum levels of DEC1 andLXRβ gradually increased and decreased,respectively（P 〈 0. 05 to P 〈 0. 01）. The serum level of DEC1 was negatively correlated withthe level of LXRβ in PD patients（ r = - 0. 326,P 〈 0. 05）. Conclusions：The serum level of DEC1 is negatively correlated with thelevel of LXRβ in PD patients,which may be involved in the onset and progression of PD.