上海地区PM2.5致慢性阻塞性肺疾病急性加重的影响因素

Multivariate factors affect the influence of PM_(2.5) on acute exacerbation of COPD in Shanghai

目的探讨慢性阻塞性肺疾病急性加重(AECOPD)发病与患者临床特征和居住环境的关系。方法纳入自2015年1月—2016年6月间就诊的AECOPD患者352例,分析其居住环境和PM_(2.5)浓度与AECOPD的相关性。结果 PM_(2.5)浓度越高,AECOPD发生次数越多,人均居住面积与马路街道的距离均与AECOPD相关。对纳入临床与居住因素行logistic多因素回归分析获得预警公式。结论高浓度PM_(2.5)暴露是AECOPD的重要诱因,与居住因素等相关。预警公式的设立对AECOPD预测和防控具有重要意义。

Objective To explore the relationship between acute exacerbation of COPD(AECOPD)and their clinical and living environment. Methods A total of 352 AECOPD patients were enrolled in the study. The co-relationship between PM_(2.5) concentration,clinical and living environment and AECOPD occurrence were analyzed. Results The higher PM_(2.5) concentration,the more AECOPD episodes occurred,which were related with clinical factors including age,sex,BMI,smoking history,FEV1% and living environment including average living space,building floor and distance to main road. Clinical and living factors were analyzed by using multivariate logistic regression to form a predictive model.Conclusion Exposure to high concentration of PM_(2.5) increases the risk of developing AECOPD. The predictive model is expected to improve the early prevention of AECOPD.