自噬与血管生成的研究进展

The progress of autophagy and angiogenesis

血管生成主要包括病理性及生理性血管生成2个方面,新生血管形成在多种疾病致病中发挥重要作用,主要包括肿瘤血管、眼底新生血管疾病(黄斑变性、糖尿病视网膜病变等),在新生血管形成中自噬起到重要作用。肿瘤生长及侵袭转移与新生血管形成具有密切的相关性,自噬性细胞死亡可能会在一定程度上对血管生成造成抑制,而自噬也可以增强抗肿瘤药物作用。但是,肿瘤组织自噬水平的提高,同时会保护肿瘤组织,导致抗肿瘤药物的耐药,通过调节自噬能够更有效地控制肿瘤。在眼底新生血管疾病中,自噬参与了新生血管形成,通过抑制自噬能够更有效地控制眼底新生血管。

Angiogenesis,composed of pathological and physiological aspects,plays an important role in many diseases,such as tumor and retinal neovascular diseases（ macular degeneration,diabetic retinopathy,et al）. In the process of angiogenesis,autophagy may play a role. Angiogenesis is required for tumor growth,invasion and metastasis. A autophagic cell death may inhibit angiogenesis to some extent,while autophagy can enhance the effects of anti-neoplastic drugs. However,the high activity of autophagy in tumor cells could protect themselves to cause their resistance to anti-tumor drugs. Thus,regulating autophagy could control the tumor more effectively. Similarly,in retinal neovascular diseases,retinal angiogenesis could be more effectively controlled through inhibiting autophagy due to its participation.