代谢综合征对双相情感障碍患者预后的影响

Effects of metabolic syndrome on clinical prognosis of patients with bipolar disorder

目的:观察代谢综合征(MS)对双相情感障碍患者预后的影响。方法:共招募临床缓解期的双相情感障碍患者212例,按照是否伴有代谢综合征分为研究组(伴有代谢综合征)和对照组(未伴有代谢综合征)。两组采用杨氏躁狂量表、蒙哥马利抑郁量表、阳性和阴性症状量表、不自主运动量表、巴恩斯静坐不能评定量表、UKU副作用评定量表、自知力评估量表、大体社会功能评估量表、WCST评估并比较患者的临床特征。结果:双相情感障碍患者中代谢综合征的发生率为30.66%,多因素回归显示:研究组比对照组患者有更多的住院次数、更严重的迟发性运动障碍,更差的自知力、整体功能和执行力。结论:代谢综合征(MS)不利于双相情感障碍患者的预后,对此类患者应加强针对性护理。

Objective： To explore effects of metabolic syndrome（ MS） on clinical prognosis of patients with bipolar disorders.Methods： A total of 212 patients with bipolar disorder of clinical remission were recruited and divided into study group（ with MS） and control group（ without MS）. The Young mania rating scale,the Montgomery-Asberg depression rating scale,the positive and negative symptom scale,the involuntary movement scale,the Barnes Akathisia rating scale,the Udvalg for Kliniske Undersogelser side effect scale,the schedule for assessment of insight,the global sssessment of dunctioning scale and the Wisconsin card sorting test（ WCST）was used to evaluate the clinical characteristics of the patients,and then the results of the two groups were compared. Results： The patients with bipolar disorders had a MS prevalence of 30.66%. The multivariate regression analysis showed that compared with the control group,the study group had more previous hospitalization times,more sever tardive dyskinesia,poorer insight,poorer global function and more impaired executive function. Conclusions： MS is unbeneficial to the prognosis of the patients with bipolar disorders. Therefore,the targeted care intervention should be given to these cases.