人附睾蛋白4检测在良恶性胸腔积液鉴别中的价值

Value of detection of human epididymis protein 4 in differentiating benign and malignant pleural effusion

目的探讨人附睾蛋白4(HE4)检测在良恶性胸腔积液鉴别中的价值。方法收集肺癌患者胸腔积液45例和肺部良性病变者53例,肺部良性病变患者中结核性胸腔积液30例,炎性胸腔积液23例。用电化学发光法测定HE4水平。结果恶性胸腔积液的HE4水平[(980.88±69.82)pmol/L]明显高于肺部良性病变[(547.84±44.35)pmol/L],差异有统计学意义(P<0.05)。肺腺癌患者胸腔积液HE4水平[(1 163.34±83.05)pmol/L]高于肺部良性病变患者,差异有统计学意义(P<0.05)。肺腺癌患者胸腔积液HE4水平明显高于鳞癌和小细胞癌,差异有统计学意义(P=0.001)。结核性胸腔积液与炎性胸腔积液中的HE4表达差异无统计学意义(P>0.05)。结论 HE4能够为良恶性胸腔积液的鉴别提供有利的参考价值。

Objective To investigate the clinical significance of detection of human epididymis protein 4（HE4）in patients with lung cancer.Methods Pleural effusion of 45 cases with lung cancer patients and 53 cases with benign pulmonary lesions,including30 cases with tuberculous pleural effusion and 23 cases with inflammatory pleural effusion.Levels of HE4 were detected by electrochemiluminescence.Results The expression level of HE4 in pleural effusion of patients with lung cancer[980.88±69.82）pmol/L]was significantly higher than that in patients with benign lung lesions[（547.84±44.35）pmol/L]（P〈0.05）.The level of HE4 in pleural effusion of patients with lung adenocarcinoma[1 163.34±83.05）pmol/L]was significantly higher than that in that in patients with benign lung lesions（P〈0.05）,which was also significantly higher than that in squamous cell carcinoma and small cell carcinoma（P〈0.05）.There was no significant difference in the expression of HE4 in tuberculous pleural effusion and inflammatory pleural effusion（P〉0.05）.Conclusion HE4 can provide a good reference value for differentiating benign and malignant pleural effusion.