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γ-干扰素释放试验在肺结核患儿中的诊断效果 被引量:3

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摘要 目的探讨γ-干扰素释放试验在儿童肺结核患者的诊断效果及对临床治疗的指导价值。方法选取2014年2月至2016年10月该院收治的100例肺结核儿童患者作为试验组(采用γ-干扰素释放试验方法),再选取健康志愿者100例作为对照组(采用结核菌素皮肤试验)。采用γ-干扰素释放试验检测试验组的血浆γ-干扰素水平;所有研究对象进行结核菌素皮肤试验;采用抗酸染色法对100例结核病患儿的痰液标本进行染色处理。采用SPSS20.0统计学软件进行统计学处理,比较两种方法的灵敏度、特异度、阳性预测值、阴性预测值等参数指标。结果γ-干扰素释放试验灵敏度、特异度、阳性预测值、阴性预测值分别为82.00%(82/100)、90.00%(90/100)、89.13%(82/92)、91.84%(90/98),显著高于结核菌素皮肤试验方法60.00%(60/100)、70.00%(70/100)、66.67%(60/90)、63.64%(70/110),差异有统计学意义(P<0.05);100例肺结核患儿抗酸染色阳性有33例,阴性有67例,其中抗酸染色法阳性肺结核患者的γ-干扰素释放试验阳性率为84.85%(28/33),阴性肺结核患者的γ-干扰素释放试验阳性率82.09%(55/67)。结论在诊断肺结核病方面,γ-干扰素释放试验方法与结核菌素皮肤试验方法相比,前者效能更高,可在临床推广。
作者 黄晴
出处 《检验医学与临床》 CAS 2017年第23期3545-3547,共3页 Laboratory Medicine and Clinic
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