咪达唑仑静脉注射对重症呼吸衰竭患者镇静效果观察

Sedative effect of intravenous midazolam in patients with severe respiratory failure

目的探讨咪达唑仑静脉注射对重症呼吸衰竭患者的镇静效果。方法将104例重症呼吸衰竭患者随机分为观察组和对照组,对照组采取常规镇静药物进行治疗,观察组采取咪达唑仑进行治疗,对比两组患者的治疗效果。结果观察组患者的镇静起效时间、达到满意深度时间以及苏醒时间明显低于对照组,差异有统计学意义(P<0.05)。两组患者麻醉前MMSE评分比较差异未见统计学意义(P>0.05)。观察组患者麻醉后6、24、48 h的MMSE评分显著高于对照组(P<0.05);观察组患者的氧合指数和末梢血氧饱和度明显高于对照组,差异有统计学意义(P<0.05)。结论对重症呼吸衰竭患者采用咪达唑仑静脉注射可以取得良好的镇静效果,同时可以使氧合指数以及血氧饱和度得到明显改善,具有临床推广价值。

Objective To investigate the sedative effect of intravenous midazolam in patients with severe respiratory failure. Methods A total of 104 patients with severe respiratory failure were randomly divided into observation group and control group. The paitents in control group received routine sedative drugs,and the observation group adopted midazolam treatment,the therapeutic effects were compared. Results The satisfactory sedation onset time,depth of time and recovery time were significantly lower in the observation group than those in the control group,the differences were significant between the two groups（ P〈0. 05）. MMSE score before anesthesia had no significant difference between the two groups（ P〉0. 05）. After 6,24,48 h of anesthesia,MMSE scores in the observation group were significantly higher than those in the control group（ P〈0. 05）. The oxygenation index and peripheral oxygen saturation in the observation group were significantly higher than those in the control group,the differences were significant（ P〈0. 05）. Conclusions Intravenous midazolam intravenous injection of severe respiratory failure can achieve good sedative effect,and can make oxygenation index and oxygen saturation improved significantly,with clinical value.