抗生素降阶梯治疗重症肺炎的疗效观察

Clinical effect of antibiotic de-escalation therapy on severe pneumonia

目的分析抗生素降阶梯治疗对于重症肺炎患者的临床疗效。方法随机选取重症肺炎患者58例,随机均分为观察组(n=29)与对照组(n=29)。对照组患者给予抗生素升级治疗,观察组患者给予抗生素降阶梯治疗。对比两组患者的临床疗效。结果观察组患者的临床疗效优于对照组,不良反应发生率低于对照组,住院时间、抗生素使用时间短于对照组,气管插管率、病死率低于对照组,差异有统计学意义(P<0.05)。结论采用抗生素降阶梯治疗重症肺炎患者,能够显著提高患者临床治愈率,降低患者气管插管率,有效缩短患者的住院时间以及抗生素使用时间,不良反应发生率低,安全可靠,值得临床推广使用。

Objective To study the clinical effect of antibiotic de-escalation therapy in patients with severe pneumonia. Methods Fifty-eight patients with severe pneumonia were randomly divided into observation group（ n = 29） and control group（ n = 29）. The control group were treated with antibiotic escalation treatment,the observation group were given antibiotic de-escalation therapy. The clinical effects of the two groups were compared. Results Compared with the control group,the rate of clinical efficacy was higher,the adverse reaction rate was lower,the average hospitalization time and antibiotic use time were shorter, the intubation rate and fatality were lower in observation group（ P〈0. 05）.Conclusions Antibiotic de-escalation therapy can significantly improve the clinical cure rate,reduce intubation rate of patients,shorten the hospital stay and antibiotic use time and reduce incidence of adverse reactions in patients with severe pneumonia. It is safe and reliable,worthy of promoting in clinical use.