不同血清学亚型Hp感染对无症状体检者血清胃功能的影响

Impact of different serological subtypes of Helicobacter pylori infection on gastric function of asymptomatic physical examiners

目的探讨不同血清学亚型幽门螺杆菌(Hp)感染对无症状体检者血清胃功能的影响。方法经Western blot检测将无症状体检人群Hp感染者135例分为尿素酶(Ure)组42例、细胞毒素相关蛋白A^+(CagA^+)组24例和CagA^+空泡细胞毒素A^+(VacA^+)组69例。另设Hp非感染者32例为阴性对照组。ELISA法检测三组血清胃功能胃蛋白酶原(PG)Ⅰ、PGⅡ和胃泌素17(G17)。结果 Ure组PGⅠ、PGⅡ、PGR(PGⅠ/PGⅡ比值)和G17与阴性对照组相比均无统计学差异(P>0.05)。CagA^+组PGⅠ和G17均高于阴性对照组,且PGⅠ高于Ure组(P<0.05)。CagA^+VacA^+组PGⅠ、PGⅡ及G17均高于阴性对照组,而PGR低于CagA^+组(P<0.05)。结论不同血清学亚型Hp感染对无症状体检者血清胃功能影响存在差异。

Objective To study the impact of different serological subtypes of Helicobacter pylori（Hp）infection on gastric function of asymptomatic physical examiners.Methods On the basis of Western blot detection,135 asymptomatic Hp-infected physical examiners were divided into groups of Ure（42 cases）,CagA~＋（24 cases）and CagA~＋VacA~＋（69 cases）.Thirty-two physical examiners without Hp-infection were taken as negative controls（group NC）.Serum levels of pepsinogen（PG）Ⅰ,PGⅡ and Gastrin 17（G17）were detected by ELISA.Results Serum levels of PGⅠ,PGⅡ,PGR（ratio of PGⅠto PGⅡ）and G17 in group Ure were similar to those in group NC（P〈0.05）.Serum levels of PGⅠ and G17 were higher in group CagA~＋than those in group NC.Serum level of PGⅠwas higher in group CagA~＋than that in group Ure（P〈0.05）.Serum levels of PGⅠ,PGⅡ and G17 in group CagA~＋VacA~＋were higher than those in group NC,but PGR was lower in group CagA~＋VacA~＋than that in group CagA~＋（P〈0.05）.Conclusion The impact of different serological subtypes of Hp infection on gastric function of asymptomatic Hp-infected people exits difference.