食管鳞癌患者TIM-3高表达与患者生存期的相关性

Correlation of high expression of TIM-3 with survival time in esophageal squamous cell carcinoma patients

目的 研究中国食管鳞状细胞癌患者中T细胞免疫球蛋白黏蛋白-3（TIM-3）的表达水平及其临床价值。方法 收集61例食管鳞癌患者术后病理标本，并行免疫组织化学方法计算评估TIM-3的表达情况。评估TIM-3的表达情况与临床病理特征之间的相关性。使用Kaplan Meier的方法进行生存分析。使用单因素分析及Cox回归模型分析TIM-3的表达水平与食管鳞癌的预后关系。结果 所有肿瘤标本中，TIM-3高强度表达比例占24.59%。TIM-3的表达水平与肿瘤浸润深度有关。通过Kaplan-Meier生存分析得出结论：与TIM-3低表达组相比，TIM-3高表达组显示了更差的疾病相关存活率（χ2＝4.630，P＝0.031）。多因素分析表明TIM-3不是食管鳞癌患者的独立预后因素。结论 TIM-3高表达的食管鳞癌患者的预后更差。TIM-3在食管鳞癌的发生发展中发挥作用。

Objuective To investigate the expression levels of T cell immunoglobulin domain and mucin domain protein-3（TIM-3）and its clinical values in esophageal squamous cell carcinoma（ESCC） in China.Methods The expression of TIM-3 was calculated by the immunohistochemical assay method from the postoperative pathological specimens of 61 patients with ESCC; χ2 test was used to evaluate the relationship between TIM-3 and the clinicopathological parameters, while survival analysis was figured out by Kaplan Meier method, as well as univariate analysis and Cox＇s proportional hazards model were used to analyze the expression of TIM-3 and its clinical prognostic value.Results The proportion of high staining intensity of TIM-3 was 24.59% in all tumor samples. Tim-3 expression in ESCC cells was correlated with the depth of tumor invasion. According to the Kaplan-Meier method for survival analysis： compared with TIM-3 low expression group, TIM3 high expression group had bad disease-specific survival （χ2=4.630, P=0.031）. Multivariate analysis showed that the expression level of TIM-3 was not the independent indicators of the prognosis of patients with ESCC.Conclusions High TIM-3 expression level is correlated with the poor prognosis of patients with ESCC. TIM-3 may play a major role in the ECSS carcinogenesis.