血清胃蛋白酶原与体重指数间的相关性用于胃癌高危人群筛查的价值

The value of the relationship between pepsinogen and BMI in screening of gastric cancer

目的探讨血清胃蛋白酶原(PG)与体重指数(BMI)之间的相关性,用于筛查胃癌高危人群。方法筛选苏南地区符合条件的983例男性为研究对象,按照成人体重分成4组:体重过低组59例,体重正常组603例,超重组181例,肥胖组140例。采用酶联免疫吸附法(ELISA)检测各组空腹血清胃蛋白酶原I(PGI)及胃蛋白酶原II(PGII)水平,计算PGI/II(PGR)比值,观察各组检测指标与BMI之间的相关性。结果随着BMI值的增加,血清PGI和PGR水平降低,差异有统计学意义(P<0.05);相比体重正常组,体重过低组及肥胖组的PGI和PGR降低,差异有统计学意义(P<0.05)。结论苏南地区体重过低和肥胖人群的PGI和PGR显著降低,其相关性对于筛查胃癌高危人群具有重要意义。

Objective To search the relationship between serum pepsinogen（ PG） and body mass index（ BMI）,in order to screen gastric cancer. Methods 983 male people were selected from south Jiangsu and divided into four groups： 59 cases in low birth weight group,603 cases in normal weight group,181 cases in overweight group,140 cases in obesity group. Enzyme linked immunosorbent assay（ ELISA） was used to detect the levels of serum PGI and PG II,count the PGI/II ratio（ PGR）,and search the relationship between PGI,PGI/II and BMI. Results With the increasing of BMI,PG I and PGR significantly decreased,with the difference statistically significant（ P〈 0. 05）. Compared with normal weight group,PGI and PGR in low weight group and obese group significantly decreased,with the differences statistically significant（ P〈 0. 05）. Conclu sion There is significant reduction in PGI and PGR in low weight group and obesity group,which has great significance for screening gastric cancer in south Jiangsu.