习惯性流产患者血清血管内皮生长因子、转化生长因子-β1水平变化及临床意义

Level changes and its significance of serum VEGF,TGF-β1 in recurrent spontaneous abortion

目的探讨习惯性流产(RSA)患者血清中VEGF、TGF-β1的变化及其意义。方法选择120例RSA患者为研究对象,其中原发性和继发性患者和对照组各60例。对血清VEGF、TGF-β1水平进行检测。结果血清VEGF、TGF-β1浓度,原发性RSA组分别为(2.41±0.52)ng/ml和(10.58±1.49)ng/ml,继发性RSA组分别为(2.25±0.63)ng/ml和(9.75±1.70)ng/ml,对照组分别为(0.92±0.39)ng/ml和(12.20±1.88)ng/ml,3组比较差异有统计学意义(P<0.01);原发性RSA组早期分别为(2.23±0.48)ng/ml和(11.06±1.24)ng/ml,晚期分别为(2.61±0.50)ng/ml和(10.04±1.57)ng/ml,继发性RSA组早期分别为(2.03±0.69)ng/ml和(10.37±1.50)ng/ml,晚期分别为(2.48±0.49)ng/ml和(9.13±1.70)ng/ml,差异有统计学意义(P<0.01);血清VEGF、TGF-β1浓度原发性组与RSA分期呈正相关(r=0.64,r=0.65,P<0.01);继发性RSA组亦与RSA分期呈正相关(r=0.63,r=0.64,P<0.01)。结论血清VEGF、TGF-β1能反映RSA炎症情况。

Objective To detect the level changes and its significance of serum VEGF,TGF-β1 in recurrent spontaneous abortion. Methods 120 cases of recurrent spontaneous abortion（ RSA） were selected as the research objects with 60 cases in primary RSA group,secondary RSA group and the control group respectively. The levels of VEGF and TGF-β1 in serum were measured. Results The levels of VEGF and TGF-β1 in the primary group were（ 2. 41 ± 0. 52） ng/ml and（ 10. 58 ± 1. 49） ng/ml,while that were（ 2. 25 ± 0. 63） ng/ml and（ 9. 75 ± 1. 70） ng/ml in the secondary RSA group,and（ 0. 92 ± 0. 39） ng/ml and（ 12. 20 ± 1. 88） ng/ml in the control group,there was statistical significance on the difference among the three groups（ P〈 0. 01）; which were（ 2. 23 ± 0. 48） ng/ml,（ 11. 06 ± 1. 24） ng/ml at the early stage of the primary RSA group and（ 2. 61 ±0. 50） ng/ml,（ 10. 04 ± 1. 57） ng/ml at the advanced stage in the primary RSA group; that were（ 2. 03 ± 0. 69） ng/ml,（ 10. 37 ± 1. 50） ng/ml at the early stage and（ 2. 48 ± 0. 49） ng/ml,（ 9. 13 ± 1. 70） ng/ml at the advanced stage in the secondary RSA group,there was statistical significance on the difference between the two groups（ P 〈0. 01）; the serum concentrations of VEGF and TGF-β1 were positively correlated with RSA grading in the primary RSA group（ r = 0. 64,r = 0. 65,P〈 0. 01）;and that in the secondary RSA group was also positively correlated with RSA grading（ r = 0. 63,r = 0. 64,P 〈0. 01）. Conclusion The serum levels of VEGF,TGF-β1 can reflect the inflammation of recurrent spontaneous abortion.