辽宁省2012年-2016年腹泻症候群细菌病原学研究分析

Etiological study and analysis of diarrhea syndrome in Liaoning Province during 2012-2016

目的了解辽宁省腹泻症候群细菌病原谱构成,对临床诊断、治疗用药与预防突发公共卫生事件提供依据。方法对2012年-2016年辽宁省腹泻症候群临床患者粪便标本检测结果进行分析,了解病原谱构成情况。结果 1 307份样本中,检出7种细菌病原核酸242份,检出率为18.52%,混合感染占4.12%。致泻性大肠埃希菌47份(3.60%),非伤寒沙门菌33份(2.52%),志贺菌7份(0.54%),副溶血性弧菌119份(9.10%),嗜水气邻单胞菌28份(2.14%),类志贺邻单胞菌6份(0.46%),霍乱弧菌2份(0.15%)。结论构成辽宁省腹泻症候群细菌病原种类繁多,主要以副溶血性弧菌、致泻性大肠埃希菌为主。其中副溶血性弧菌是本地区主要的细菌感染病原。

Objective To understand the constitution of the bacterial pathogens of diarrhea syndrome in Liaoning Province,so as to provide basis for clinical diagnosis,treatment and prevention of public health emergencies. Methods The test results of stool specimens from clinical patients with diarrhea syndrome in Liaoning Province during 2012-2016 were analyzed to understand the composition of the pathogenic spectrum. Results In the 1 307 samples,242 samples including 6 bacterial nucleic acid pathogens were detected,with a detection rate of 18. 59% and mixed infection of 4. 12%. Among them,diarrhea Escherichia coli was detected in 47 samples（ accounting for 3. 6%）,non-typhoid Salmonella in 33 samples（ 2. 52%）,Shigella in 7 samples（ 0. 54%）,Vibrio parahaemolyticus in 119 samples（ 9. 10%）,Pseudomonas aeruginosa in 28 samples（ 2. 14%）,Pseudomonas schizophyllum in 6 samples（ 0. 46%）,and Vibrio cholera in 2 samples（ 0. 15%） respectively. Conclusion Composition of bacterial pathogens of diarrhea syndrome in Liaoning Province had a wide range,mainly based on Vibrio parahaemolyticus and diarrheal Escherichia coli. Vibrio parahaemolyticus was the main pathogen of bacterial infection in the region.