GPS评分对预测肝内胆管结石合并肝内胆管癌肝切除术的预后价值

Prognostic value of the Glasgow Prognostic Score in patients with hepatolithiasis-associated intrahepatic cholangiocarcinoma

目的探讨术前Glasgow预后分数(Glasgow prognostic score,GPS)与肝内胆管结石合并肝内胆管癌(hepatolithiasis-associated intrahepatic cholangiocarcinoma,HLAIHCC)术后预后之间的关系。方法回顾性分析接受根治性肝切除治疗的52例肝内胆管结石合并肝内胆管癌病人的临床病理资料,并对临床病理结果及预后进行统计分析。应用Kaplan-Meier法描绘生存曲线,Cox回归模型分析影响其预后的因素。结果 GPS是肝内胆管结石合并肝内胆管癌病人术后总体生存的独立危险因素。GPS评分为2的病人其淋巴转移(P=0.029)和肿瘤为Ⅲ-Ⅳ期比例大(P=0.007)。结论 GPS评分是肝内胆管结石合并肝内胆管癌病人肝切除术后预后的独立危险因素。

Objective To explore the association between preoperative glasgow prognostic score（ GPS） and prognosis in hepatolithiasis-associated intrahepatic cholangiocarcinoma（ HLAIHCC） patients underwent liver resection. Methods Clinical data of 52 consecutive HLAIHCC patients who underwent hepatectomy were retrospectively reviewed. The clinical and pathological date and prognosis was analyzed. The curves of overall survival were depicted using the Kaplan-Meier method. Cox proportional hazard models tested the associations between variables and prognosis. Results GPS was an independent risk factor of overall survival of IHHCC. Patients with a GPS 2 had more lymph node metastasis（ P = 0. 029） and more TMN Ⅲ-Ⅳ（ P = 0. 007）. Conclusions GPS is an independent risk factor of prognosis of HLAIHCC patients who underwent liver resection.