摘要
目的回顾分析影响鼻腔NK/T细胞淋巴瘤预后的因素。方法搜集2010~2017年收治的鼻腔NK/T细胞淋巴瘤患者112例,采用Kaplan-Meier法进行单因素生存分析并进行Cox多因素分析。结果全组5年样本数24例,1年、3年、5年生存率分别为92%、72%、54%。单因素分析显示年龄、性别、白蛋白水平、Ki-67阳性率、治疗模式(放疗、化疗、放化疗联合)、首发症状至确诊时间、首次治疗完全缓解与鼻腔NK/T细胞淋巴瘤的预后相关。多因素分析显示症状首次出现时间至确诊时间及Ki-67阳性率大于50%为影响鼻腔NK/T淋巴瘤预后的独立危险因素。结论症状首次出现时间至确诊时间及Ki-67阳性率可作为评价鼻腔NK/T淋巴瘤预后的参考因素。
OBJECTIVE To investigate the prognosis of nasal NK/T cell lymphoma. METHODS The clinical data of 112 patients with a primary diagnosis of nasal NK/T cell lymphoma treated at the First Hospital of Zhengzhou University between January 2010 and June 2017 were studied. The association between clinical parameters and survival rate was evaluated by Kaplan-Meier method and Cox regression model. RESULTS The 1-, 3-, 5-year overall survival were 92%, 72% and 54% respectively. Single factor analysis displayed that age, gender, the level of albumin, the expression level of Ki-67, treatment model, complete response rate to the primary treatment and the interval between symptom onset to diagnosis were related to the prognosis factors. Multivariate analysis showed that the interval of first time of symptom onset to the time of diagnosis and the positive rate of Ki-67 more than 50% were the independent risk factors for the prognosis of nasal NK/T lymphoma. CONCLUSION The interval of symptom onset to the time of diagnosis and the positive rate of Ki-67 may be independent prognostic factors for NK/T cell lymphoma.
出处
《中国耳鼻咽喉头颈外科》
CSCD
2017年第11期593-596,共4页
Chinese Archives of Otolaryngology-Head and Neck Surgery
