变应性鼻炎的治疗对伴有哮喘患者生活质量的影响

Effect of treatment of allergic rhinitis on quality of life in patients with asthma

目的探讨变应性鼻炎的治疗对伴有哮喘患者的生活质量的影响。方法 53例未经正规治疗的中-重度变应性鼻炎患者,均伴轻-中度持续性哮喘,已予丙酸氟替卡松/沙美特罗治疗。在此基础上予氯雷他定口服,丙酸氟替卡松鼻喷雾剂喷鼻,症状控制后,以维持剂量继续治疗,共12周。治疗前后采用变应性鼻炎视觉模拟量表评分、哮喘控制测试、哮喘生活质量问卷进行评估。结果治疗后变应性鼻炎症状改善情况,显效率为75%,有效率为21%,无效率为4%;哮喘总控制率由74%升至91%,经过统计学分析,哮喘控制有明显改善(P<0.05);哮喘生活质量问卷评分在4个维度及总分上均较前升高,差异有统计学意义(P<0.01)。结论有效的治疗变应性鼻炎有益于伴有轻-中度哮喘患者的哮喘控制,并提高其生活质量。

OBJECTIVE To investigate the effect of the treatment of allergic rhinitis on the quality of life of patients with bronchial asthma. METHODS Fifty-three patients with moderate-severe allergic rhinitis and mild-moderate asthma were included in this study and all of them had not yet received treatment for allergic rhinitis. There were 20 males and 33 females with an age ranged from 18 to 76 years. They had been treated with Salmeterol/Fluticasone propionate（seretide） 50/100 μg twice a day and combined with Ventolin if needed. On this basis, they were treated with loratadinel0 mg and Fluticasone proplonate nasal spray 200 micrograms once daily for 12 weeks. The visual analog scale, the asthma control test and Juniper＇s asthma quality of life questionnaire were recorded before and after treatment. RESULTS After treatment of allergic rhinitis, the rate of full asthma control was 28%, the rate of partial asthma control was 63%, and the rate of uncontrolled asthma was 9%. There was a significant improvement in asthma control after treatment of allergic rhinitis（P〈0.05）. The scores after treatment were higher than that before treatment in all dimensions of asthma quality of life questionnaire（P〈0.01）. CONCLUSION Allergic rhinitis and bronchial asthma are two closely related diseases, treatment of allergic rhinitis is benefit to bronchial asthma control and can improve the quality of life of the patients.