疾病中的氧化应激和细胞自噬

Oxidative Stress and Cell Autophagy in Disease

自噬过程可将细胞内废弃的长寿命蛋白,运送到自噬溶酶体中进行降解。自噬一方面可维持细胞稳态,另一方面还可在细胞处于饥饿、营养缺乏等过度刺激下促进其生存或诱导其凋亡。有研究表明,许多疾病状态下,机体内过量活性氧和氧化应激的产生会激活细胞内的自噬。文章对目前研究较多的血管疾病、神经退行性疾病及衰老状态下,自噬在氧化应激状态下的作用进行了综述。

Autophagy,which is made by the formation of the autophagy lysosomal,will be abandoned in the cells of long-lived proteins,transported to the lysosomal degradation. Autophagy not only can maintain the cell homeostasis,but also can promote the survival or death of cells under the stimulation of cell starvation and nutritional deficiency. The studies have indicated that in a number of disease states,excessive ROS and oxidative stress in the body can activate autophagy in cells. This review summarizes the role of autophagy in the production of excess reactive oxygen species in the disease states.