摘要
目的:探讨重组人脑利钠肽(rh BNP)与硝普钠(SNP)联合治疗急性失代偿性心力衰竭的临床疗效。方法:选取2014年8月至2016年8月间我院收治的66例急性失代偿性心力衰竭患者,随机分为对照组和观察组两组,对照组在常规治疗的基础上采用硝普钠静脉泵入治疗,观察组在对照组治疗的基础上联合rh BNP静脉泵入进行治疗,对两组的效果进行比较。结果:观察组治疗的显效率和总有效率均明显高于对照组,差异具有统计学意义(P<0.05);治疗1 h和24 h后两组患者的肺毛细血管楔压(PCWP)不同程度降低,左心室射血分数(LVEF)升高(P<0.05),并且观察组患者的变化更为明显(P<0.05);治疗72 h后,两组患者的血清肿瘤坏死因子-α(TNF-α)和高敏C反应蛋白(hs CRP)水平较之治疗前均有不同程度的下降(P<0.05),观察组下降的程度更为明显(P<0.05)。结论:对于急性失代偿性心力衰竭患者,在常规治疗的基础上联合应用重组人脑利钠肽可迅速改善患者的血流动力学,改善心功能,降低炎症反应程度,值得临床推广。
Objective:To observe the clinical effect of recombinant human brain natriuretic peptide combined with sodium nitroprusside in the treatment of acute decompensated heart failure. Method:66 patients with acute decompensated heart failure in our hospital from August 2014 to August 2016 were selected and randomly divided into two groups: control group and observation group. In control group, patients were treated by sodium nitroprusside intravenous infusion, and in observation group, patients were treated by rhBNP intravenous injection combined with sodium nitroprusside. The effects of the two groups were compared. Results:The significant efficiency rate and total effective rate of observation group were higher than control group(P<0.05). The PCWP were reduced and LVEF were increased after 1 h and 24 h(P<0.05), and the improvements of observation group were significant than control group(P<0.05). 72 hours after treatment, the levels of TNF-α and hs CRP in observation group were significantly lower than those in the control group(P<0.05), and the decreasing of observation group was significant than control group(P<0.05). Conclusion:Combined using of recombinant human brain natriuretic peptide and sodium nitroprusside in patients with acute decompensated heart failure can significantly improve hemodynamics, cardiac function and reduce the level of inflammatory reaction. It is worth for generalization.
出处
《黑龙江医药》
CAS
2017年第6期1249-1252,共4页
Heilongjiang Medicine journal
