趋化因子受体7表达与肺癌相关性的Meta分析

Correlation between lung cancer and chemokine receptor 7 expression： a Meta-analysis

目的系统评价趋化因子受体7（CCR7）表达与肺癌及其临床病理特征的相关性。方法利用计算机检索PubMed、EMbase、CBM、CNKI、VIP和WanFang Data数据库，搜集相关病例-对照研究。采用RevMan 5.3软件进行Meta分析，计算效应量比值比（OR）及其95%可信区间（CI），采用Cochrane Q检验法检验异质性（α＝0.10）。结果最终纳入16个研究，其中肺癌1 189例，癌旁正常肺组织130例；正常肺组织40例。Meta分析结果显示：肺癌CCR7表达高于癌旁正常肺组织[OR＝13.80，95%CI（7.68，24.80），P＝0.000]和正常肺组织[OR＝86.13，95%CI（11.29，657.11），P＝0.000]；肺癌CCR7表达与淋巴结转移[OR＝5.08，95%CI（2.75，9.37），P＝0.000]及临床分期[OR＝0.43，95%CI（0.22，0.81），P＝0.009]有关。结论CCR7表达与肺癌及其临床病理特征有显著相关性。

ObjectiveTo systematically evaluate the correlation between lung cancer and chemokine receptor 7 （CCR7） expression, as well as its clinicopathological features.MethodsA detailed literature search was carried out in related databases such as PubMed, EMbase, CBM, CNKI, VIP and WanFang Data. Meta-analysis was performed by RevMan 5.3 software. Odds ratio （OR） and 95% confidence interval （CI） were calculated. Heterogeneity was tested by Cochrane Q test （α=0.10）.ResultsFinally, 16 studies were included, containing 1 189 lung tumor cases, 130 adjacent and 40 normal lung tissue cases. As compared with the adjacent and normal lung tissues, the expression of CCR7 in lung cancer tissues was significantly up-regulated [OR=13.80, 95%CI （7.68, 24.80）, P=0.000; OR=86.13, 95%CI （11.29, 657.11）, P=0.000, respectively]. CCR7 expression was related to clinical stages [OR=5.08, 95%CI（2.75, 9.37）, P=0.000] and lymph node metastasis [OR=0.43, 95%CI（0.22, 0.81）, P=0.009].ConclusionOur study indicates that CCR7 expression is significantly correlated with lung cancer and its clinicopathological features.