老年冠心病患者脂联素和同型半胱氨酸水平及其与血管内皮功能的相关性研究

Adiponectin and HCY levels in elderly patients with coronary heart disease and their correlation with vascular endothelial function

目的:探讨老年冠心病患者脂联素(ADP)和同型半胱氨酸(HCY)及其与血管内皮功能的相关性。方法:选择老年冠心病患者73例为观察组,健康体检老年人73例为对照组,行临床指标检测和彩色多普勒超声检查。结果:观察组血清ADP、肱动脉内径基础(D0)、肱动脉反应性充血后内径值(D1)、肱动脉血流介导的舒张功能(FMD)低于对照组(P<0.05)。观察组HCY高于对照组(P<0.05)。ADP与D0、D1、FMD呈负相关性。HCY与D0、D1、FMD呈正相关性。结论:老年冠心病患者血清ADP降低,伴HCY升高。ADP与血管内皮功能呈负相关性,而HCY与血管内皮功能呈正相关性。

Objective:To investigate ADP and HCY in elderly patients with coronary heart disease and their correlation with vascular endothelial function.Methods:73 elderly patients with coronary heart disease were observation group.73 healthy elderly people were control group.Clinical indicators and color doppler ultrasonography examination finished.Results:Serum ADP,basal diameter of brachial artery,internal diameter of brachial artery after reactive hyperemia,FMD in observation group were lower than control group(P<0.05).HCY in observation group was higher than control group(P<0.05).ADP was negative correlation with D0,D1,FMD.HCY was positive correlation with D0,D1,FMD.Conclusion:ADP decrease while HCY increase in elderly patients with coronary heart disease.ADP is negative correlation with vascular endothelial function.HCY is positive correlation with vascular endothelial function.