血清LBP、25-(OH)D及MIP-3α水平在诊断原发性胆汁性肝硬化中的临床意义

Study on clinical significance of combined detection of LBP,25-(OH)D and MIP-3αin diagnostic process of PBC

目的:研究脂多糖结合蛋白(LBP)、25-羟基维生素D[25-(OH)D]及巨噬细胞炎性蛋白3α(MIP-3α)联合检测对原发性胆汁性肝硬化的诊断价值。方法:收治原发性胆汁性肝硬化(PBC)患者80例,乙型肝炎患者75例,以及进行健康体检的80例健康人群作为对照人群,分别为HBV组与正常对照组。然后对上述所有研究对象血清中LBP、25-(OH)D及MIP-3α水平行定量检测,并进行统计学分析。结果:在PBC组中,患者血清LBP与MIP-3α均明显高于HBV组与正常对照组患者(P<0.05),而该组患者25-(OH)D水平低于HBV组与正常对照组(P<0.05);与治疗前进行比较,PBC组患者治疗后其血清LBP与MIP-3α水平降低(P<0.05),而25-(OH)D水平明显升高(P<0.05);与单独检测进行比较,LBP、25-(OH)D及MIP-3α联合检测具有更高的敏感度与特异度(P<0.05),且此时ROC曲线面积最大。结论:针对原发性胆汁性肝硬化的诊断,LBP、25-(OH)D及MIP-3α联合检测更准确,其临床应用价值更大。

Objective:To study on clinical significance of combined detection of LBP,25-(OH)D and MIP-3αin diagnostic process of PBC.Methods:80 patients with PBC were treated in our hospital.In the same period,there were 75 patients with hepatitis B(HBV group)for treatment and 45 healthy people for health examination in our hospital(normal control group).The level of LBP,25-(OH)D and MIP-3αin serum was detected quantitatively,and the data were statistically analyzed.Results:The level of LBP and MIP-3αin serum in PBC group were significantly higher than the HBV group and normal control group(P<0.05),while the level of 25-(OH)D was lower in PBC group(P<0.05);compared with pre-treatment,the level of LBP and MIP-3αin serum in PBC group were significantly lower after treatment(P<0.05)and the level of 25-(OH)D were higher;compared with single detection,sensitivity and specificity were highest by combining detection of LBP,25-(OH)D and MIP-3α(P<0.05),with the largest area of the ROC curve.Conclusion:It can diagnose PBC accurately by combined detection of LBP,25-(OH)D and MIP-3α,with important clinical value.