基于数据挖掘方法分析中药外用疗法治疗颈肩腰腿痛用药规律

Analysis on external application of herbs regularity for pain in neck, shoulders, waist and legs

[目的]分析和挖掘治疗颈肩腰腿痛的中药外用处方用药组方规律。[方法]通过中医传承辅助平台(Ⅴ2.5)软件,分析自1980年1月至2017年5月期间已发表文献中有效的中药外用处方的用药组方规律。[结果]共筛选出145个有效处方,包含188味中草药,使用频次总和为1582次,其中红花出现频次最高。频次在30次以上的两味药组合有14组;频次在15次以上的三味药有56组,四味药有8组。通过药物之间的关联规律,演化得出三味药的核心组合16个,四味药的核心组合2个,新处方2个。[结论]临床中治疗颈肩腰腿痛的中药外用药物以祛风湿类药物为主,兼配以活血化瘀类、补虚类、清热类、解表类、理气类、温里类等药物,共凑祛风除湿、活血通络之效。

[Objective] To analyze the composing principles of the prescriptions of external application of herbs for pain in neck, shoulders,waist and legs on Traditional Chinese Medicine(TCM) Inheritance Support System(Ⅴ2.5). [Methods] Efforts were made to collect 188 related prescriptions from January 1980 to May 2017. Then enter the data into the TCM inheritance support system,and analyze the data by using frequency analysis, association rules, complex system entropy clustering and unsupervised hierarchical clustering. [Results]Totally 145 prescriptions were screened out for the analysis, including 188 herbs. And the total frequency was 1582. The most frequently used one was Flos Carthami. Among the prescriptions, there were 14 combinations of two herbs with frequency of more than 30, and there were 56 and 8 combinations of three and four herbs with the frequency of more than 15 times. Through the association rules among herbs,16 core combinations and two new prescriptions were evolved. [Conclusion] Clinically, external herbs for pain in neck, shoulders, waist and legs were mainly the herbs for expelling wind-damp, and cooperated with the herbs for invigorating the circulation of blood, tonifying deficiency, clearing heat, relieving exterior syndrome, regulating qi, warming interior and so on. These herbs could drive rheumatism and invigorate the circulation.