多囊卵巢综合征与肠道菌群的关系和小檗碱的干预作用研究进展

Research advance in the relationship between the polycystic ovary syndrome and gut microbiota and the intervention effect of berberine

多囊卵巢综合征发病的病理生理基础是胰岛素抵抗,肠道菌群是存在于人类肠道中的微生物,是后天获得并影响人体自身平衡的重要"器官",研究表明肠道菌群的失调可以引起胰岛素抵抗,因此多囊卵巢综合征与肠道菌群存在密切联系。目前研究认为小檗碱通过改善肠道菌群以治疗胰岛素抵抗等代谢异常性疾病,小檗碱可以通过对多囊卵巢综合征患者肠道菌群的干预来治疗多囊卵巢综合征。文章就多囊卵巢综合征与肠道菌群的关系及小檗碱通过对肠道菌群的干预作用治疗多囊卵巢综合征做一综述。

The pathogenesis of polycystic ovary syndrome pathophysiological basis is insulin resistance. Gut microbiota is acquired important "organ", found in human intestinal flora and affect the body 's own balance. Studies suggest that the gut microbiota imbalance can cause insulin resistance, so closely linked with polycystic ovary syndrome and gut microbiota. The present study showed the gut microbiota was improved by berberine in treatment of insulin resistance and other metabolic abnormalities disease. Berberine can through the intervention of gut microbiota to treat polycystic ovary syndrome. This article reviewed the relationship between polycystic ovary syndrome and gut microbiota and berberine on gut microbiota of intervention effect in the treatment of polycystic ovary syndrome.