雾化吸入重组人干扰素α1b治疗小儿急性毛细支气管炎的疗效评估

Evaluation on Curative Effect of Atomizing Inhalation of Recombinant Human Interferon α1b for Pediatric Acute Bronchiolitis

目的:探讨雾化吸入重组人干扰素α1b治疗小儿毛细支气管炎的疗效和安全性。方法:选取2015年1月~2017年2月收治的小儿急性毛细支气管炎患儿186例为研究对象,随机分为治疗组和对照组,每组各93例。两组患儿均给予常规对症治疗,治疗组加用重组人干扰素α1b注射液雾化吸入,比较两组治疗后主要疗效指标和次要疗效指标消失时间、治疗总有效率、并发细菌感染率、不良反应等。结果:治疗组患儿主要及次要疗效指标消失时间短于对照组,差异有统计学意义(P<0.05)。治疗组患儿治疗总有效率87.1%,明显高于对照组总有效率(72%),差异有统计学意义(P<0.05)。并发细菌感染率治疗组6.5%,低于对照组(10.8%),差异有统计学意义(P<0.05)。两组均无明显不良反应发生。结论:雾化吸入重组人干扰素α1b治疗小儿急性毛细支气管炎疗效显著,不良反应少,值得临床推广应用。

Objective To discuss the curative effect and safety of atomizing inhalation of recombinant human interferon α1 b for pediatric acute bronchiolitis. Method 186 cases of pediatric acute bronchiolitis who had been treated in the Department of Pediatrics of the hospital since Jan. 2015 by Feb. 2017 were taken as research objects,they were randomly divided into the treatment group and the control group,93 cases in each group. While both groups were given symptomatic treatment,the treatment group were given atomizing inhalation of recombinant human interferon α1 b injection. The time for the disappearing of the preliminary curative effect index and the secondary curative effect index,the general effective rate of treatment,concurrent bacterial infections rate,and adverse reactions,etc. were compared for both groups. Results The time for the disappearing of the preliminary curative effect index and the secondary curative effect index of the treatment group was shorter than that of the control group（P〈0. 05）. The general effective rate of the treatment group was 87. 1%,which was obviously above 72% which was the control group＇s general effective rate（P〈0. 05）. The concurrent bacterial infections rate of the treatment group was 6. 5%,below 10. 8%,which was that of the control group（P〈0. 05）. Both groups had no adverse reactions. Conclusion Atomizing inhalation of recombinant human interferon α1 b has obvious effect for pediatric acute bronchiolitis,and it has few adverse reaction,thus it is worth being promoted for clinic applicati.