自体外周血造血干细胞移植治疗恶性淋巴瘤29例

Hematopoietic Stem Cell Transplantation from Autologous Peripheral Blood in the Treatment of Malignant Lymphoma

目的:观察自体外周血造血干细胞移植治疗恶性淋巴瘤的临床效果。方法:选取恶性淋巴瘤患者58例进行分析,随机分为两组。观察组给予自体外周血造血干细胞移植治疗,对照组给予常规化疗方法治疗,每组29例患者。结果:观察组的治疗总有效率显著较高,即观察组为68.97%,对照组为31.03%,差异有统计学意义(P<0.05)。此外,观察组的并发症发生率为13.80%,对照组为41.37%(P<0.05)。结论:临床对恶性淋巴瘤患者采用自体外周血造血干细胞移植方法治疗,取得了较好的临床效果,且患者出现的并发症比较少。

Objective:To investigate efficacy of hematopoietic stem cell transplantation from the autologous peripheral blood in the treatment of malignant lymphoma patients.Methods:58 patients with malignant lymphoma had been randomly assigned into the observation group treated with hematopoietic stem cell transplantation from autologous peripheral blood and the control groupwith conventional chemotherapy,29 patients in each group.The treatment efficacyand the incidence of complications of two groups had been compared by Chi-squaretest.Results:The therapeutic effect in the observation group was higher than that in the control group,respectively 68.97% and 31.03%(P <0.05),with less complications(13.80% versus 41.37%)(P<0.05).Conclusion:The therapy of hematopoietic stem cell transplantation from autologous peripheral blood can significantly improve the therapeutic effect(68.97%)and the survival rate of the malignant lymphoma with less complications,compared with the conventional chemotherapy(31.03%)(P<0.05).