酚妥拉明和多巴胺联合治疗小儿重症肺炎的效果评价

Efficacy of Phentolamine and Dopamine in the Treatment of Severe Pneumonia in Children

目的:研究酚妥拉明与多巴胺联合应用治疗小儿重症肺炎的临床疗效。方法:以2014年1月-2017年3月笔者所在医院收治的60例小儿重症肺炎患儿作为研究对象,采取计算机随机数字分组法将患儿随机分为两组,每组30例,对照组采取常规治疗,观察组在常规治疗的同时,采用酚妥拉明与多巴胺联合治疗,比较两组患儿的临床疗效、症状缓解时间、不良反应发生率及肺通气功能指标。结果:观察组患儿的总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组咳嗽气促、发热、肺啰音等症状缓解时间均较对照组显著缩短,差异有统计学意义(P<0.05);观察组患儿的不良反应发生率与对照组患儿相比差异无统计学意义(P>0.05);经过治疗后,两组患儿肺通气功能指标均较治疗前显著改善,差异有统计学意义(P<0.05),而治疗后,观察组的各项指标均优于对照组,差异有统计学意义(P<0.05)。结论:采用酚妥拉明、多巴胺联合治疗小儿重症肺炎的临床疗效显著,值得肯定,可有效促进临床症状缓解和肺功能改善,防止并发症发生,且其安全性也相对可靠。

Objective：To study clinical curative effect of combined application of Phentolamine and Dopamine in the treatment of severe pneumonia in children.Method：From January 2014 to March 2017 years, 60 cases of children with severe pneumonia in our hospital were selected as the research object,and randomly divided into two groups by computer random number method,30 cases in each group,the control group received conventional treatment,the observation group in the conventional treatment at the same time,using phentolamine and dopamine treatment,compared the clinical efficacy of two groups,the remission time,the incidence of adverse reaction and pulmonary ventilation function index.Result：In the observation group,the total efficiency was significantly higher than the control group（P〈0.05）;the observation group in cough and dyspnea,fever,pulmonary rales and other symptoms time were significantly shorter than the control group（P〈0.05）;the adverse reaction rate in the observation group and the control group had no statistical difference（P〈0.05）;after treatment,two groups of children with pulmonary function were significantly improved compared with that before treatment（P〈0.05）,and after treatment,the indicators of observation group were better than the control group（P〈0.05）.Conclusion：Using Phentolamine and Dopamine combined,clinical curative effect of the treatment of children with severe pneumonia is significant,worthy of recognition,can effectively promote the relief of clinical symptoms and improve lung function,prevent the occurrence of complications,and its safety is relatively reliable.